| 新型补体抑制剂对同基因大鼠移植肾功能的长期影响 |
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| 引用本文： | 董隽,王晓雄,肖序仁,洪宝发.新型补体抑制剂对同基因大鼠移植肾功能的长期影响[J].军医进修学院学报,2001,22(3):205-207. |
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| 作者姓名： | 董隽 王晓雄 肖序仁 洪宝发 |
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| 作者单位： | 解放军总医院泌尿外科 |
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| 摘 要： | 目的：观察新型补体抑制剂APT070对同基因大鼠移植肾功能的长期影响。方法：应用同基因大鼠肾脏移植模型，供肾移植前分别经观察药物APT070、对照药物APT898及肾脏灌注液灌注，测定术后4－20周移植肾功能及24h尿蛋白含量。结果：肾移植术后4－20周，APT070灌注组移植肾功能明显好于对照组，24h尿蛋白含量明显低于对照组，P＜0．01。结论：APT070作为一种可与肾脏组织结合的新型补体抑制剂，可改善同基因大鼠移植肾的长期功能。
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| 关 键 词： | 肾功能试验 肾移植 补体灭活剂 大鼠 APT070 |
Complement inhibition by a novel membrane-targeted complement regulator improves long-term renal isograft function in the rat |
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| DONG Jun,WANG Xiao xiong,XIAO Xu ren,HONG Bao fa.Complement inhibition by a novel membrane-targeted complement regulator improves long-term renal isograft function in the rat[J].Academic Journal of Pla Postgraduate Medical School,2001,22(3):205-207. |
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| Authors: | DONG Jun WANG Xiao xiong XIAO Xu ren HONG Bao fa |
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| Abstract: | Objective:to observe the effects of a novel membrane targeted complememt regulator on long term renal function after rat kidney transplantation Methods:Donor kidneys were perfused with APT070, APT898, and Collins solution before isograft kidney transplantation Renal functions and 24 hour urine protein were measured 4~20 weeks after transplantation Results: Renal functions and 24 hour urine protein were significantly improved by perfusing donor kidney with APT070( P <0 01) Conclusion: APT070, a novel membrane targeted complement regulator can improve long term renal isograft function |
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| Keywords: | renal function tests kidney transplantation complement inactivators |
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