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丝穗金粟兰根中的一个新倍半萜
引用本文:王吓长,吴伟群,马世平,刘静涵,胡立宏.丝穗金粟兰根中的一个新倍半萜[J].中国天然药物,2008,6(6):404-407.
作者姓名:王吓长  吴伟群  马世平  刘静涵  胡立宏
作者单位:1. 中国药科大学中药学院,南京,210009;中国科学院上海药物研究所上海中药现代化研究中心,上海,201203
2. 浙江普洛医药科技有限公司,东阳,322118
3. 中国药科大学中药学院,南京,210009
4. 中国科学院上海药物研究所上海中药现代化研究中心,上海,201203
基金项目:the National Natural Science Foundation of China,国家自然科学基金资助项目
摘    要:目的:研究丝穗金粟兰根的化学成分。方法:采用硅胶、MCI和RP-18等多种层析柱分离手段,运用NMR和MS等波谱技术鉴定化合物的结构。结果:从丝穗金粟兰根中分离并鉴定了5个倍半萜化合物:chloranthatone(1),atractylenolactam(2),chloranthalactone C(3),atractylenolid Ⅲ(4)和shizuka-acoradienol(5)。结论:化合物1为新的吉马烷型倍半萜,化合物2为首次从该属植物中分离得到。

关 键 词:丝穗金粟兰  倍半萜  吉马烷  化学成分

A New Sesquiterpenoid from the Roots of Chloranthus fortunei
WANG Xia-Chang,WU Wei-Qun,MA Shi-Ping,LIU Jing-Han,HU Li-Hong.A New Sesquiterpenoid from the Roots of Chloranthus fortunei[J].Chinese JOurnal of Natural Medicines,2008,6(6):404-407.
Authors:WANG Xia-Chang  WU Wei-Qun  MA Shi-Ping  LIU Jing-Han  HU Li-Hong
Affiliation:WANG Xia-Chang1,2,WU Wei-Qun3,MA Shi-Ping1,LIU Jing-Han1,HU Li-Hong2* 1School of Traditional Chinese Medicine,China Pharmaceutical University,Nanjing 210009,2Shanghai Research Center for Modernization of Traditional Chinese Medicine,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,3Zhejiang Apeloa Medical Technology Co.,Ltd,Dongyang 322118,China
Abstract:AIM: To study the chemical constituents of the roots of Chloranthus fortunei.METHODS: The chemical constituents were isolated and purified using column chromatographies and the structures were elucidated on the basis of spectral analysis.RESULTS: Five compounds were obtained and their structures were identified as chloranthatone (1), atractylenolaetam (2), chloranthalactone C (3), atractylenolid Ⅲ (4) and shizuka-acoradienol (5).CONCLUSION: Compound 1 is a new germacrane sesquiterpenoid, and compound 2 has been isolated from this genus for the first time.
Keywords:Chloranthus fortunei  Sesquiterpenoid  Germacrane  Chemical constituents
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