甘精胰岛素联合阿卡波糖对老年2型糖尿病患者血糖及β细胞功能的影响

目的观察甘精胰岛素（IG）联合阿卡波糖治疗老年2型糖尿病（T2DM）的降糖效果及对13细胞功能的影响。方法将90例口服药联合治疗空腹血糖（FPG）控制不佳的老年rr2DM患者，随机分为甘精胰岛素（IG）联合阿卡波糖组和中性鱼精蛋白锌胰岛素（NPH）组。治疗12周后比较两组治疗前后FPG、餐后2h血糖（2hPG）、糖化血红蛋白（HbAlC）、空腹C肽及餐后2hC肽水平。并对两组低血糖发生率进行比较。结果治疗12周后两组FPG、2hPG、HbAlc均下降，IG联合阿卡波糖组低血糖发生较NPH组少，治疗后c肽升高显著，与NPH组比较差异有统计学意义（P〈0．05）。结论甘精胰岛素联合阿卡波糖能较好地控制老年2型糖尿病患者血糖及糖化血红蛋白，且低血糖发生率较低，与NPH比较，安全性更高。

Effectiveness of Acarbose combined with Glargine in blood glucose and function of Beta Cell in eldly Type 2 Diabetes Mellitus

Objective To investigate the effect of insulin glargine (IG)Eon plasma glucose, beta cell function in eldly type 2 diabetes mellitus (T2 DM) patients. Methods Ninety eldly patients with poor fasting plasma glucose(FPG) control on oral antidiabetic agents with T2 DM were randomly divided into two groups:IG combined with Acarbose group, supplied with Acarbose before meals and glargine at bedtime, NPH group were supplied NPH before meals and NPH at bedtime. The changes of some clinical indexes FPG, 2 h postprandial blood glucose (2 hPG),HbA1 c, C-peptide ] in each group were observed before and after treatment. The ratio of hypoglycaemia was compared between two groups. Results The levels of FPG ,2 hPG, HbA1 c were significantly decreased after treatment in both groups(P＜0.05). In the IG combined with Acarbose group ,there was a lower accuracy of hypoglycaemia and a significant increase of C peptide after treatment compared with NPH group ,with significant differences (P＜0.05). Conclusion It is more effective and safer for eldly diabetic patients to use IG combined with Acarbose to decrease BG. Arcabose combined with IG can control high plasma glucose well on elder patients with T2 DM and the incidence of hypoglycemia is low.