重型颅脑损伤伴失血性休克与应激性溃疡的相关性研究

 目的 探讨重型颅脑损伤伴失血性休克与应激性溃疡的相互关系.方法 回顾性分析2002年1月～2006年12月本院收治的326例重型颅脑损伤患者的临床资料,根据有无合并失血性休克分为两组,统计两组患者发生应激性溃疡的情况,同时测定胃液和血液的pH值,并进行统计学处理.结果 326例重型颅脑损伤患者总共发生应激性溃疡79例(24.2%),其中45例为失血性休克,占失血性休克的39.8%(45/113),无休克发生时应激性溃疡发生率为15.9%,两组比较差异非常显著(P<0.01);伤后第2天血液中的pH值差异非常显著(P<0.01),第7天无统计学意义(P>0.05);两组患者伤后第2天和第7天胃液中的pH值无统计学意义(P>0.05).结论 重型颅脑损伤伴有失血性休克时更易发生应激性溃疡.

Relation ship between severe brain injury with hemorrhagic shock and stress ulcer

Objective To study the relationship between severe brain injury with hemorrhagic shock and stress ulcer.Methods The data of 326 patients with severe craniocerebral injury adnitled in this hospital between January 2002 and December 2006,were divided into two groups according to presence or absence of hemorrhagic shock. Stress ulcer was receded, and gastric juice and blood pH at different periods were analyzed for the two groups. Results Stress ulcer developed in 39.8 % （45/113）of patients with hemorrhagic shock and 15.9（34/213） of patients aithont hemorrhagic shock, with significant difference between the two groups （ P 〈 0.01 ）. Blood pH differed significantly （ P 〈 0.01） on day 2 but not on day 7（ P 〉 0.05） after injury between the two groups.There was no significant differences in gastric juice pH no days 2 and 7 after injury between the two groups （P〉0.05）. Conclusions Severe craniocerebral injury associated with hemorrhagic shock is liable to develop stress ulcer.