苍砂白芥汤联合平消胶囊对子宫肌瘤患者T淋巴细胞亚群、性激素水平和子宫动脉血流指数的影响

目的:探讨苍砂白芥汤联合平消胶囊治疗子宫肌瘤的临床疗效及对患者T淋巴细胞亚群、性激素水平和子宫动脉血流指数的影响。方法:选择2018年12月～2019年12月我院收治的子宫肌瘤患者90例为研究对象,采用随机数字表法及随机余数分组法分为对照组(30例,给予米非司酮片治疗)、观察1组(30例,给予米非司酮片+平消胶囊治疗)和观察2组(30例,给予米非司酮片+平消胶囊+苍砂白芥汤治疗),治疗3个月后比较三组中医临床疗效、肌瘤体积、T淋巴细胞亚群、性激素水平、子宫动脉血流指数和不良反应。结果:临床总有效率观察2组为96.67%,观察1组为86.67%,对照组为70.00%,三组比较差异有统计学意义(P0.05);治疗3个月后,三组卵泡刺激素(FSH)、孕酮(P)、雌二醇(E_2)水平较治疗前降低,且治疗3个月后观察2组低于观察1组,观察1组低于对照组,观察2组肌瘤体积、子宫动脉阻力指数(RI)、子宫动脉搏动指数(PI)低于观察1组和对照组(P0.05);治疗3个月后三组CD3~+、CD4~+及CD4~+/CD8~+水平较治疗前明显升高,CD8~+水平较治疗前明显降低,观察1组、观察2组CD3~+、CD4~+及CD4~+/CD8~+水平高于对照组,CD8~+水平低于对照组(P0.05)。三组不良反应的发生率比较差异无统计学意义(P0.05)。结论:苍砂白芥汤联合平消胶囊可提高子宫肌瘤患者的治疗效果,改善患者的T淋巴细胞亚群、性激素水平和子宫动脉血流指数,且并未增加药物不良反应。

Effects of Cangsha Baijie Decoction and Pingxiao Capsule on T-lymphocyte Subgroup, Sex Hormone Level and Uterine Artery Blood Flow Index in Patients with Hysteromyoma

ABSTRACT Objective: To explore the effects of Cangsha Baijie decoction and Pingxiao capsule on T-lymphocyte subgroup, sex hormone level and uterine artery blood flow index in patients with hysteromyoma. Methods: 90 patients with hysteromyoma who were admitted to our hospital from December 2018 to December 2019 were selected as the study subjects. The patients were divided into control group (30 cases, treated with mifepristone tablets), observation group 1 (30 cases, treated with mifepristone tablets, Pingxiao capsule) and observation group 2 (30 cases, treated with mifepristone tablets, Cangsha Baijie decoction, Pingxiao capsule) by random number table method and random remainder grouping method. 3 months after treatment, the clinical efficacy, myoma volume, T lymphocyte subsets, sex hormone levels, uterine artery blood flow index and adverse reactions of the three groups were compared. Results: The total clinical effective rate was 96.67% in the observation group 2, 86.67% in the observation group 1 and 70.00% in the control group. There was significant difference in the three groups (P<0.05). 3 months after treatment, The levels of follicle stimulating hormone (FSH), progesterone (P), estradiol (E2) were lower than those before treatment, the observation group 2 were lower than those in the observation group 1, the observation group 1 was lower than those in the the control group. The resistance index (RI) and pulsation index (PI) of uterine artery in the observation group 2 were better than those in the observation group 1 and the control group, the differences were significant (P<0.05). 3 months after treatment, the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in the three groups were significantly higher than those before treatment, the level of CD8⁺ was significantly lower than that before treatment. The levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in observation group 1 and observation group 2 were higher than those in control group, while the levels of CD8⁺ in observation group 1 and observation group 2 were lower than those in control group, the differences were significant (P<0.05). There was no significant difference in the incidence of adverse reactions among the three groups. Conclusion: Cangsha Baijie decoction combined with Pingxiao capsule can improve the therapeutic effect, T lymphocyte subsets, sex hormone level and uterine artery blood flow index of patients with hysteromyoma, without increasing adverse drug reactions.