胃痛消痞方对功能性消化不良肝郁模型大鼠胃肠运动影响的实验研究

目的：观测胃痛消痞方对功能性消化不良（FD）肝郁模型大鼠血浆胃动素（MTL）,血清NO,小肠推进比的影响,进而探讨该药对胃肠运动的影响。方法：夹尾激怒法制作FD肝郁模型,60只大鼠随机分为正常组、模型组、吗丁啉组、中药低、中、高剂量组。每日2次灌胃14天后,检测各组大鼠血浆MTL含量,血清NO含量,小肠推进比;比较中药各组的疗效。结果：胃痛消痞方可显著升高血浆MTL含量,降低血清NO含量,加快小肠推进速度,统计学有显著性差异（P〈0.01）;且中剂量组疗效优于低剂量组（P〈0.01,P〈0.05）,等效于高剂量组（P〉0.05）。结论：胃痛消痞方能促进FD肝郁型大鼠胃肠运动,中剂量组疗效最佳。

The Experimental Study of Weitongxiaopi Decoction Influence on Gastrointestinal Motility in Functional Dyspepsia Rats with Liver Depression

Objective：To observe the effect of weitongxiaopi decoction （WTXPD） in functional dyspepsia（FD） rats with liver depression by measuring plasma motilin （MTL） level,serum NO level and small intestinal propulsive ratio,further to approach the influence of this decoction on gastrointestinal motility.Methods：To establish FD model by clipping tail,and 60 rats were randomly divded into：Normal group,Model group,Domperidone group,WTXPD low dose,middle dose,large dose group.Different groups rats were treated twice aday by gastrogavage for 14 days,then to measure plasma MTL level,serum NO level and small intestinal propulsive ratio of each group rats and to contrast the effective extent of different dose WTXPD.Results：WTXPD could advance plasma MTL level,reduce serum NO level,and accelerate small intestinal propulsive ratio of FD rats significantly,there was significant difference in statistics（P〈0.01）.The efficacy of middle dose WTXPD was superior to low dose group（P〈0.01,P〈0.05）,and similar with large dose group（P〉0.05）.Conclusion：WTXPD could improve gastrointestinal motility of FD rats with liver depression,and medium dose WTXPD,the optimal dose,was the most effective.