左甲状腺素钠片联合甲状腺片用于甲状腺癌术后TSH抑制治疗的临床效果评价

摘要 目的：探究左甲状腺素钠片联合甲状腺片用于甲状腺癌术后促甲状腺激素（TSH）抑制治疗的临床效果。方法：选择2021年1月-2022年6月本院收治的甲状腺癌手术并进行碘131清甲治疗后行TSH抑制治疗的80例患者为本次研究对象，开展动态分组法，对照组及观察组，n=40。单纯左甲状腺素钠片治疗为对照组，左甲状腺素钠片联合甲状腺片治疗为观察组。比较甲状腺功能、肝肾功能、治疗效果及不良反应。结果：治疗后，游离三碘甲状腺原氨酸（FT3）、游离四碘甲状腺原氨酸（FT4）水平，观察组及对照组均较治疗前提高，但观察组低于对照组；TSH水平，两组均较治疗前降低，且观察组较对照组低（P＜0.05）；治疗前，肌酐（Scr）、谷丙转氨酶（ALT）、谷草转氨酶（AST）水平，观察组及对照组比较无差异（P＞0.05），治疗后，各指标水平，两组均较治疗前降低，且观察组较对照组低（P＜0.05）；观察组治疗有效率高于对照组（P＜0.05）；观察组及对照组不良反应率比较无差异（P＞0.05）。结论：左甲状腺素钠片联合甲状腺片用于甲状腺癌术后TSH抑制治疗可明显改善患者甲状腺功能，提高免疫功能及治疗效果，效果优于左甲状腺素钠片单独治疗，且安全性较高。

Clinical Evaluation of Levothyroxine Sodium Tablets Combined with Thyroid Tablets for TSH Suppression Therapy after Thyroid Cancer Surgery

ABSTRACT Objective: To explore the clinical effect of levothyroxine sodium tablets combined with thyroid tablets in the treatment of thyroid-stimulating hormone (TSH) suppression after thyroid cancer surgery. Methods: From January 2021 to June 2022, 80 patients with thyroid cancer who underwent thyroid cancer surgery and received iodine 131 ablation therapy and then underwent TSH suppression therapy were selected as the research objects. Dynamic grouping method was carried out. The matched group and observation group, n=40. The matched group was treated with levothyroxine sodium tablets alone, and the observation group was treated with thyroid tablets combined on the basis of the matched group. The thyroid function, liver and kidney function, therapeutic effect and adverse reactions were compared. Results: Post-treatment, the levels of free triiodothyronine (FT3) and free tetraiodothyronine (FT4) were higher in the observed group and matched group than pretherapy, but the observation group was lower than the matched group, the TSH level, the observation group and matched group were lower compared with before treatment, and the observation group was lower than the matched group (P<0.05); Post-treatment, Scr, ALT, AST levels, observation group and matched group were not different (P>0.05). Post-treatment, each index level, observation group and matched group were reduced compared with pretherapy, and the observation group was lower than the matched group (P<0.05); the treatment effective rate of the observation group was higher than that of the matched group (P<0.05); Comparison of adverse reaction rate between group and matched group (P>0.05). Conclusion: Levothyroxine sodium tablets combined with thyroid tablets for TSH suppression therapy after thyroid cancer surgery can significantly improve thyroid function, improve immune function and therapeutic effect.