| 基于酪氨酸酶抑制作用的白术水提工艺研究 |
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| 引用本文： | 刘永琴,罗忠圣,徐昌艳,钱志瑶,杨宏,覃容贵.基于酪氨酸酶抑制作用的白术水提工艺研究[J].中国现代应用药学,2020,37(10):1196-1202. |
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| 作者姓名： | 刘永琴 罗忠圣 徐昌艳 钱志瑶 杨宏 覃容贵 |
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| 作者单位： | 贵州医科大学 药学院,贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室),贵州医科大学 药学院,贵州医科大学 公共卫生学院,贵州医科大学 药学院,贵州省高等学校天然药物药理与成药性评价特色重点实验室;贵州省高等学校天然药物药理与成药性评价特色重点实验室 |
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| 基金项目： | 贵州省2019年大学生创新创业训练计划项目（20195200925） |
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| 摘 要： | 摘要：目的 优化白术的提取工艺。方法 在单因素试验基础上，利用响应面法以料液比、提取次数、提取时间为因素，提取物的产率、提取物对酪氨酸酶的抑制率为响应值，确定白术的最佳水提工艺，研究其美白效果。结果 白术的最佳提取工艺条件为：料液比1∶14(g/mL)，提取次数3次，提取时间2.5 h，在此条件下白术提取物的产率可达到64.4％；提取物对酪氨酸酶的抑制率可达到65.16％。结论 白术提取物的产率、提取物对酪氨酸酶的抑制率的实测值和预测值基本一致，具有较好的美白效果。
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| 关 键 词： | 响应面法 白术 酪氨酸酶 提取工艺 |
| 收稿时间： | 2019/3/15 0:00:00 |
| 修稿时间： | 2020/4/7 0:00:00 |
Study on Water Extraction Technology of Atractylodis Macrocephalae Rhizoma Based on Inhibitory Effect of Tyrosinase |
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| LIU Yongqin,LUO Zhongsheng,XU Changyan,QIAN Zhiyao,YANG Hong,QIN Ronggui.Study on Water Extraction Technology of Atractylodis Macrocephalae Rhizoma Based on Inhibitory Effect of Tyrosinase[J].The Chinese Journal of Modern Applied Pharmacy,2020,37(10):1196-1202. |
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| Authors: | LIU Yongqin LUO Zhongsheng XU Changyan QIAN Zhiyao YANG Hong QIN Ronggui |
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| Affiliation: | Pharmacy School, Guizhou Medical University,Pharmacy School, Guizhou Medical University, Key Laboratory of natural product of chemistry,Pharmacy School, Guizhou Medical University,School of Public Health, Guizhou Medical University,Pharmacy School, Guizhou Medical University,The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability, Guizhou Medical University, The joint laboratory of Guizhou Medical University-the captial of Guiyang |
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| Abstract: | ABSTRACT: OBJECTIVE To optimize the extraction technology of Atractylodis macrocephalae rhizoma. METHODS Using water/solid ratio,extraction times, extraction duration as response factors, the yield and the inhibitory activity against tyrosinase of the extracts as response value,based on single factor test, reponse surface method was used to obtain the optimal extraction technology of Atractylodis macrocephalae rhizoma and its whitening effect was tested . RESULTS The result showed that the optimal conditions were: the water/solid ratio of 1:14, the extraction time of 3, extraction duration of 2.5 hours. Under the optimal condition,the yield of Atractylodis macrocephalae rhizoma extract was 64.4% and the inhibition rate of extract on tyrosinase was 65.16%. CONCLUSION The yield of Atractylodis macrocephalae rhizoma extract and the inhibition rate of extract on tyrosinase were basically similar with the predicted values. It has good whitening effect. |
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| Keywords: | response surface methodology atractylodis macrocephalae rhizoma tyrosinase extraction pro-Cess |
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