男性2型糖尿病患者伴非酒精性脂肪肝病的性激素变化——附53例报告

目的：探讨男性2型糖尿病（T2DM）伴非酒精性脂肪肝病（NAFLD）患者性激素变化情况。方法：53例男性T2DM患者按有无合并NAFLD分为脂肪肝组（26例）和对照组（27例），检测两组性激素水平、糖脂代谢指标及氨基转移酶水平，比较两组间的差异。结果：脂肪肝组HDL-C、性激素结合蛋白（SHBG）、卵泡刺激素（FSH）显著低于对照组（P〈0．05），体质量指数、腰臀比、三酰甘油、ALT、AST、雌二醇高于对照组（P〈0．05），两组总睾酮、黄体生成素、催乳素比较差异均无统计学意义（P〉0．05）。结论：与单纯T2DM男性患者相比，他DM伴NAFLD男性患者雌二醇水平升高，SHBG、FSH降低。

Changes of serum sex hormones levels in male patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease

Objective： To investigate the levels of sex hormones in type 2 diabetes mellitus （T2DM） patients with non-alcoholic fatty liver disease （NAFLD）. Methods： Fifty-three male patients with T2DM were divided into NAFLD group （ patients with NAFLD, n = 26） and control group （ patients without NAFLD, n = 27 ） according to the results of liver ultrasound check-up. The levels of serum sex hormones, fasting blood lipids, fasting plasma glucose （FPG）, glycosylated hemoglobin A1c （HbA1c） and transaminase of each patient were all detected. The difference of the above mentioned indexes between the two groups was compared. Results： The levels of HDL-C, sex hormone binding-globulin （SHBG） and follicle-stimulating hormone （FSH） in NAFLD group were lower than those in control group, while BMI, WHR, TG, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, and estradial （E2） in NAFLD group were higher than those in control group. On the other hand, there were no significant differences between the two groups in age, systolic blood pressure （SBP）, diastolic blood pressure （ DBP）, FPG, HbA1c, total testosterone （TT）, luteilizing hormone （LH） prolactin （PRL）. Conclusion： NAFLD in male T2DM patients had led to increased level of E2 and decreased levels of both SHBG and FSH. T2DM patients should pay attetion to prevent getting NAFLD, so as to avoid sexual dysfunction.