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Developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development
Authors:Patrick G Holt  Danny Mok  Debasis Panda  Lynnsey Renn  Giulia Fabozzi  Nick H deKlerk  Merci MH Kusel  Michael Serralha  Elysia M Hollams  Barbara J Holt  Peter D Sly  Ronald L Rabin
Affiliation:1. Telethon Kids Institute, University of Western Australia, Perth, Australia;2. Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Md;3. Child Health Research Centre, University of Queensland, Brisbane, Australia
Abstract:
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  • Keywords:Type 1 and type 3 interferons  persistent wheeze  asthma development  infant respiratory tract infections  febrile lower respiratory tract infections  hygiene hypothesis  innate immune development  CAS  Perth Childhood Asthma Study  CBMC  Cord blood mononuclear cell  fLRI  Febrile lower respiratory tract infection  ISG  Interferon-stimulated gene  LRI  Lower respiratory tract infection  OR  Odds ratio  poly(I:C)  Polyinosinic-polycytidylic acid  qPCR  Quantitative PCR  T1/3IFN  Type 1 and 3 interferon  TLR  Toll-like receptor
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