Indoxyl derivatives of drug metabolites |
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| Authors: | J W Faigle H Stierlin H Mory T Winkler H -P Kriemler |
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| Affiliation: | (1) Ciba-Geigy Limited, CH-4002 Basel, (Switzerland);(2) Present address: Research and Development Department, Pharmaceuticals Division, Ciba-Geigy Limited, Basel;(3) Present address: Physics Department, Central Function Research, Ciba-Geigy Limited, Basel |
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| Abstract: | Summary Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism. |
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| Keywords: | Drug metabolism indoxyl derivatives aldehyde intermediates benzodiazepines benzophenones |
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