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Combination Chemotherapy with Tegafur-Uracil (UFT), Etoposide, Adriamycin and Cisplatinum (UFT-EAP) for Advanced Gastric Cancer |
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| Authors: | Hayakawa Makoto; Morise Kimitomo; Chin Kensho; Sugihara Makoto; Morooka Yutaka; Maeda Hiroshi; Hattori Tastsuo; Saito Hidehiko |
| Affiliation: | 1 Department of Gastroenterology, Meitetsu Hospital Nagoya 2 First Department of Internal Medicine, Nagoya University School of Medicine Nagoya 3 Department of Surgery, Japanese Red Cross First Nagoya Hospital Nagoya |
| Abstract: | Thirty-four patients with advanced gastric cancer were treatedwith combination chemotherapy employing Tegafur-Uracil (UFT),etoposide, Adriamycin, and Cisplatinum (CDDP) (UFT-EAP therapy).An objective partial response was obtained in 16 patients (47%)and the median duration of remission was 12.2 months. The 50%survival time for all 34 patients was 10 months. Patients withmoderately or well differentiated adenocarcinoma responded well(13/19, 68%), while those with undifferentiated adenocarcinomashowed a poor response (3/15, 20%). Six responding patientswere noted to have no evidence of viable cancer at the primarysite by endoscopic biopsy, and underwent gastrectomies. Theresected specimens showed complete disappearances of the primarytumors in four patients. The median survival time for the patientsreceiving gastrectomies was 24 months. The regimen was verywell tolerated, apart from moderate bone marrow suppression.Our results suggest that patients with advanced gastric cancercan be effectively treated with UFT-EAP chemotherapy |
| Keywords: | Combination chemotherapy Gastric cancer with UFT EAP chemotherapy |
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