阿司匹林间歇疗法在脑卒中二级预防中的临床价值

目的观察阿司匹林间歇疗法与常规疗法在脑卒中二级预防中临床价值的差异。方法收集250例脑卒中恢复期患者,按随机单盲开放对照原则分为间歇疗法组(间歇组)(每8周内停药1周)和常规疗法组(单规组)各125例,均给予阿司匹林100mg Qd治疗2年。结果(1)2组脑卒中再发率无明显差异;(2)2组患者的血小板聚集率和凝血功能无明显差异;(3)间歇组上消化道出血、腹痛、腹泻等不良反应发生率较常规组明显下降(P<0.01)。结论阿司匹林间歇疗法较常规疗法能有效减低了长期治疗导致的消化道不良反应,同时有效降低脑卒中的再发率,在脑卒中二级预防中具有重要的临床应用价值。

The clinical significance of aspirin intermittent treatment in the secondary prophylaxis of stroke

Objective To observe the clinical significance between aspirin intermittent treatment and it's routine treatment in the secondary prophylaxis of stroke.Methods 250 patients with post-stroke were divided into two groups by random, including the intermittent treatment group one week without aspirin in 8 weeks and the routine group. The dose of aspirin was 100 mg every day during two years treatment in two groups.Results There was not difference of recurrence rates after stroke between two groups. In platelet aggregation collective rates and the clotting function there was not significantly different between the two groups. Compared to the routine group, the rates of upper gastrointestinal hemorrhage or other gastrointesinal adverse reactions (stomachache, diarrhea) significantly decreased in the intermittent treatment group (P< 0.01 ).Conclusions The intermittent treatment with aspirin may decrease the rates of upper gastrointestinal hemorrhage and the recurrence rate after stroke.