| 常用中药陈皮、枳实和枳壳的研究进展及质量标志物的预测分析 |
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| 引用本文： | 许姗姗,许浚,张笑敏,张铁军,刘昌孝.常用中药陈皮、枳实和枳壳的研究进展及质量标志物的预测分析[J].中草药,2018,49(1):35-44. |
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| 作者姓名： | 许姗姗 许浚 张笑敏 张铁军 刘昌孝 |
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| 作者单位： | 天津中医药大学中药学院, 天津 300193,天津中医药大学中药学院, 天津 300193;天津药物研究院 天津市中药质量控制技术工程实验室, 天津 300193,天津中医药大学中药学院, 天津 300193,天津药物研究院 天津市中药质量控制技术工程实验室, 天津 300193;天津药物研究院 释药技术与药物代谢动力学国家重点实验室实验室, 天津 300193,天津药物研究院 天津市中药质量控制技术工程实验室, 天津 300193;天津药物研究院 释药技术与药物代谢动力学国家重点实验室实验室, 天津 300193 |
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| 基金项目： | 国家自然科学基金重点项目（81430096）；国家中药标准化项目（ZYBZH-Y-JX-27） |
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| 摘 要： | 柑橘属中药陈皮Citri Reticulatae Pericarpium、枳实Aurantii Fructus Immaturus、枳壳Aurantii Fructus均为常用理气药,但三者在功效、主治方面各有侧重。从本草考证、化学成分、药理作用3个方面对芸香科柑橘属中药陈皮、枳实、枳壳进行总结、比较与分析,进一步基于质量标志物(Q-marker)的核心概念并结合药效、药性、药动学的研究进行分析,对其质量标志物进行预测,为建立和完善药材质量标准提供理论依据。
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| 关 键 词： | 中药 陈皮 枳实 枳壳 质量标志物 质量控制 |
| 收稿时间： | 2017/10/16 0:00:00 |
Research progress on Citri Reticulatae Pericarpium, Aurantii Fructus Immaturus, and Aurantii Fructus and Q-marker predictive analysis |
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| XU Shan-shan,XU Jun,ZHANG Xiao-min,ZHANG Tie-jun and LIU Chang-xiao.Research progress on Citri Reticulatae Pericarpium, Aurantii Fructus Immaturus, and Aurantii Fructus and Q-marker predictive analysis[J].Chinese Traditional and Herbal Drugs,2018,49(1):35-44. |
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| Authors: | XU Shan-shan XU Jun ZHANG Xiao-min ZHANG Tie-jun and LIU Chang-xiao |
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| Affiliation: | College of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,College of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,College of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Center for New Drug Evaluation and Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China and Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Center for New Drug Evaluation and Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | Citri Reticulatae Pericarpium, Aurantii Fructus Immaturus, and Aurantii Fructus belong to the traditional Chinese medicine derived from citrus and are commonly used for regulating vital (Qi in Chinese). But these three are different in the function, efficacy and therapeutic. Based on the concept of Q-marker and the combination of pharmacodynamics, pharmacological and pharmacokinetic studies, their quality markers were predicted. The prediction study provides a theoretical basis for establishing and improving the quality standard of the medicinal materials. |
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| Keywords: | Chinese materia medica Citri Reticulatae Pericarpium Aurantii Fructus Immaturus Aurantii Fructus quality marker quality control |
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