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Pathological effects on mice by gambierol, possibly one of the ciguatera toxins |
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| Authors: | Emiko Ito Fumie Suzuki-ToyotaKiyotaka Toshimori Haruhiko FuwaKazuo Tachibana Masayuki SatakeMakoto Sasaki |
| Affiliation: | a Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan b Department of Anatomy and Developmental Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan c Department of Chemistry, Graduate School of Sciences, The University of Tokyo, and CREST, JST, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan d Graduate School of Life Sciences, Tohoku University, Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan |
| Abstract: | Gambierol was isolated from Gambierdiscus toxicus, which causes ciguatera fish poisoning. The acute toxicological effects induced in mice by synthesized gambierol were studied. The lethal doses were about 80 μg/kg by i.p. and i.v., and 150 μg/kg by p.o. The main injury by this toxin was observed in the lung, and secondary in the heart, resulting in systemic congestion. Another toxic effect was seen in the stomach, inducing hypersecretion and ulceration. With survival from the severe stage during the initial 3 h, recovery was favorable, especially after 4 days. Additional effects were not evident during 1-week post-administration observation. |
| Keywords: | Gambierol Pathological effect Mouse Alveolar macrophage |
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