Calcium phosphate/block copolymer hybrid porous nanospheres: Preparation and application in drug delivery |
| |
| Authors: | Ke-Wei Wang Feng Chen Shao-Wen Cao |
| |
| Affiliation: | State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China |
| |
| Abstract: | Calcium phosphate (CaP)/block copolymer hybrid porous nanospheres were synthesized by a simple solution method using CaCl2 and (NH4)2HPO4 in the presence of a block copolymer at room temperature. X-ray diffraction showed that the sample consisted of amorphous calcium phosphate (ACP). The BET specific surface area and the pore size distribution of the CaP/PLLA-mPEG hybrid porous nanospheres were also characterized. The as-prepared CaP/PLLA-mPEG hybrid porous nanospheres were explored as drug carriers, and showed a high ibuprofen loading capacity and in vitro prolonged drug release behavior in a simulated body fluid. These CaP/block copolymer hybrid porous nanospheres exhibit a great potential for application in drug delivery. |
| |
| Keywords: | Calcium phosphate Block copolymer Nanosphere Drug delivery |
| 本文献已被 ScienceDirect 等数据库收录！ |
