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Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease
Affiliation:1. Research Center for Industries of the Future, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang, China;2. Westlake Laboratory of Life Sciences and Biomedicine, 18 Shilongshan Road, Hangzhou 310024, Zhejiang, China;3. College of Life Sciences, Fudan University, Shanghai 200433, China;4. Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China;1. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China;2. Department of Allergy, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;3. Department of Nuclear Medicine, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;1. Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA;2. Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), 8093 Zürich, Switzerland;3. Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, 6500 Bellinzona, Switzerland;4. Department of Genetics & Development, Columbia University Irving Medical Center, New York, NY 10032, USA;1. Department of Integrative Structural and Computational Biology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA;2. Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA;3. HHMI Faculty Scholar, Chevy Chase, MD 20815, USA;1. Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;2. Broad Institute of MIT and Harvard, Cambridge, MA, USA;3. Chemical Biology Program, Harvard University, Cambridge, MA, USA;4. Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, USA;5. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA;6. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA;7. Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA;8. Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA;9. Howard Hughes Medical Institute, Chevy Chase, MD, UA;1. NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA;2. Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA;3. Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA;1. Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA;2. Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China;3. Medical Scientist Training Program, Mayo Clinic, Rochester, MN 55905, USA;4. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA;5. Jinzhou Medical University, Shanghai East Hospital, Shanghai 200120, China;6. Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN 55905, USA;7. Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200092, China
Abstract:
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  • Keywords:tRNA splicing  tRNA splicing endonuclease  RNA metabolism  splicing mechanism
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