抑郁对老年慢性阻塞性肺疾病患者生存影响的五年随访研究

目的 探讨抑郁对老年慢性阻塞性肺疾病(COPD)患者5年生存率的影响.方法 401例符合诊断标准的老年COPD患者纳入研究,进行综合医院抑郁量表(HAD-D)评分,按照是否合并抑郁分为抑郁组和非抑郁组.以患者死亡或者完成5年随访为研究终点,比较两组患者5年生存率.结果 Kaplan-Meier分析结果表明,抑郁组患者5年生存率低于非抑郁组(log-rank法,χ~2=6.94,P<0.01);COX比例风险分析表明,抑郁独立于其他因素,与COPD患者死亡相关(HR:1.84,95%CI:1.08～3.11).结论 合并抑郁的老年COPD患者5年生存率降低,抑郁是老年COPD患者5年生存的独立影响因素.

To evaluate the impact of depression on 5-year suvival rate of elderly patients with chronic obstructive pulmonary disease

Objective To evaluate the impact of depression on 5-year survival rate of elderly patients with chronic obstructive pulmonary disease (COPD).Methods From January 2002 to June 2004, a total of 401 elderly inpatients with COPD were enrolled.They were assigned into two groups according to their HAD-D scores: depression group (HAD-D scores≥8) and non-depression group (HAD-D scores<8).The follow-up time was 5 years.Results The 5-year survival rate was lower in depression group than in non-depression group (log-rank test, χ~2 = 6.94, P<0.01).Depression was independently associated with mortality in elderly patients with COPD (HR: 1.84, 95% CI: 1.08 to 3.11).Conclusions Depression in elderly COPD patients is associated with poor 5-year survival rate, and it is an independent influencing factor of 5-year mortality.