癌表观遗传调控与癌症治疗

基因功能与表达模式异常是癌症的主要特征.日益增多的研究表明,DNA甲基化(DNAmethylation)、组蛋白修饰(histone modification)、染色质重塑(chromatin remodeling)以及microRNAs 介导的基因沉默等表观遗传调控方式的异常与癌症的发生发展密切相关.阐明癌症发生发展...

Epigenetics and cancer: target epigenetic alterations in tumor

Cancer is a heterogeneous disease which arises primarily from the accumulation of mutations in the cells^,DNA. However, recent work has implicated epigenetic changes in the etiology and progression of cancer. For example, abnormal patterns of histone methylation have been identified in breast cancer, raising the possibility that altered patterns of epigenomics can be exploited both as a biomarker to monitor disease status and as a novel therapeutic target. Here, we discuss current knowledge on epigenetic rgulation in cancer progression and treatment, with emphasis on the perspective on drug and target discovery of DNA methylation and histone modification.