氟哌噻吨美利曲辛联合复方消化酶治疗功能性消化不良的疗效观察

目的 研究氟哌噻吨美利曲辛联合复方消化酶治疗功能性消化不良的临床疗效。方法 选择2016年1月—2018年1月开封市中心医院的102例功能性消化不良患者作为研究对象，采用抽签法将患者随机分为对照组和观察组，每组各51例。对照组患者在饭后30 min口服复方消化酶胶囊，2粒/次，3次/d。观察组患者在对照组的基础上分别于早晨和中午口服氟哌噻吨美利曲辛片，1片/次，2次/d。两组患者均治疗4周。观察两组患者的临床疗效，同时比较两组治疗前后的汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）和中医症候评分。结果 治疗后，观察组的总有效率为94.12%，明显高于对照组的78.43%（P<0.05）。治疗后，观察组的HAMA和HAMD评分均明显降低（P<0.05），且观察组HAMA和HAMD评分明显低于对照组（P<0.05）。治疗后，对照组症状评分均明显降低（P<0.05），观察组各症状评分有所降低，但明显高于对照组（P<0.05）。结论 氟哌噻吨美利曲辛联合复方消化酶能显著提高功能性消化不良的疗效，减轻抑郁、焦虑状况，缓解躯体症状，具有一定的临床推广应用价值。

Clinical observation of fupentixol and melitracen combined with compound digestive enzyme in treatment of functional dyspepsia

Objective To study the clinical effect of fupentixol and melitracen combined with compound digestive enzyme in treatment of functional dyspepsia. Methods A total of 102 patients with functional dyspepsia in Kaifeng Central Hospital from January 2016 to January 2018 were selected as the study subjects. The patients were randomly divided into control group and observation group by lottery, with 51 patients in each group. Patients in the control group were po administered with Compound Digestive Enzyme Capsules at 30 min after meals, 2 grains/time, three times daily. Patients in observation group were po administered with Flupentixol and Melitracen Tablets on the basis of the control group in the morning and noon, 1 tablet/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy in two groups were observed, HAMA and HAMD scores, and TCM syndrome scores before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 94.12%, which was significantly higher than 78.43% in the control group (P<0.05). After treatment, HAMA and HAMD scores in the observation group were significantly decreased (P<0.05), and HAMA and HAMD scores in the observation group were significantly lower than those in the control group (P<0.05). After treatment, scores of symptoms in the control group were significantly decreased (P<0.05), scores of TCM symptoms in the observation group were decreased, but it was significantly higher than those in the control group (P<0.05). Conclusion Fupentixol and melitracen combined with compound digestive enzyme could significantly improve the efficacy of functional dyspepsia, alleviate depression and anxiety, and alleviate somatogenic symptoms, so it has certain clinical application value.