Changes in cytomegalovirus seroprevalence in pregnant Japanese women—A 10-year single center study |
| |
| Affiliation: | 1. Department of Maternal-Fetal Neonatal Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan;2. Department of Information Technology and Management, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan;1. Clinic of Infectious Diseases, University of Bari, Italy;2. Clinic of Infectious Diseases, University of Foggia, Italy;3. Scientific Direction, Clinical Epidemiology Unit, IRCCS San Matteo Foundation, Pavia, Italy;1. Janssen Research & Development LLC, Titusville, NJ, USA;2. Janssen Infectious Diseases BVBA, Beerse, Belgium;3. Vertex Pharmaceuticals Incorporated, Cambridge, MA, USA;4. Transgene SA, Cambridge, MA, USA;5. Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany;1. Review Division, Pharmaceuticals & Medical Devices Agency (PMDA), Kasumigaseki 3-3-2, Chiyoda-ku, Tokyo 100-0013, Japan;2. Pre-Clinical Development, GlaxoSmithKline K.K., Sendagaya 4-6-15, Shibuya-ku, Tokyo 151-8566, Japan;3. Research & Development, Sanofi K.K., Nishi Shinjuku 3-20-2, Shinjuku-ku, Tokyo 163-1488, Japan;4. Pathology Department, The Chemo-Sero-Therapeutic Research Institute, Kyokushi Kawabe 1314-1, Kikuchi-shi, Kumamoto 869-1298, Japan;5. Research Division, Chugai Pharmaceutical Co. Ltd., Komakado, 1-135, Gotemba, Shizuoka 412-8513, Japan;6. Global Regulatory Affairs Department, Shionogi Co. Ltd., Shibuya 2-17-5, Shibuya-ku, Tokyo 150-8673, Japan;1. Laboratory of Immunovirology, Department of Infectious Diseases, Universitary Hospital Ramón y Cajal, 28034 Madrid, Spain;2. IrsiCaixa-HIVACAT, Institut de Recerca en Ciències de la Salut Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, 08916 Barcelona, Spain;1. Department of Microbiology, Tikrit University College of Medicine, Tikrit, Iraq;2. Kirkuk Health Authority, Iraq;3. Department of Medicine, Tikrit University College of Medicine, Tikrit, Iraq;4. Asthma, Allergy Centre, Tikrit Teaching Hospital, Tikrit, Iraq;5. Department of Dermatology, Tikrit University College of Medicine, Tikrit, Iraq |
| |
| Abstract: | BackgroundHuman cytomegalovirus (CMV) causes congenital infections during pregnancy, and seroepidemiological data are important for estimating the risk of infection. However, only a few reports of CMV seroprevalence exist for pregnant Japanese women.ObjectivesThe purpose of this study was to assess CMV seroprevalence in pregnant Japanese women.Study designThis cross-sectional study involved pregnant Japanese women who delivered from 2003 to 2012 at our hospital (n = 15,616). Among these women, 14,099 (90.3%) underwent tests for the presence of CMV IgG. Those with an equivocal test result were excluded (n = 195) from this analysis, leaving a study sample of 13,904 Japanese pregnant women. The prevalence of CMV IgG was also assessed by calendar year, age, and parity.ResultsThe overall CMV IgG prevalence rate was 66.0%. CMV IgG prevalence significantly decreased over the course of 10 years from 2003 to 2012 (from 69.9% in 2003 to 65.2% in 2012) (p < 0.001). Adjusted odds ratios for CMV IgG positivity in women aged <25, 25–30, 35–40, and >40 years were 1.66 (95%CI: 1.25–2.20), 1.20 (95%CI: 1.07–1.35), 1.16 (95%CI: 1.07–1.26), and 1.44 (95%CI: 1.28–1.62), respectively, compared to women aged 30–35 years. Adjusted odds ratios for CMV IgG positivity for a parity of 1, 2, and ≥3 were 1.14 (95%CI: 1.06–1.23), 1.52 (95%CI: 1.32–1.77), and 2.54 (95%CI: 2.69–3.84), respectively, compared to nulliparous women.ConclusionWe found that 34% of pregnant Japanese women were susceptible to CMV infection. Calendar year, maternal age, and parity were significantly associated with changes in CMV seroprevalence among this population. |
| |
| Keywords: | Seroprevalence Pregnancy Cytomegalo virus |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
