韶关地区人群ABO、Rh、MN、P及Jk~(a-b-)血型分布

目的了解韶关地区人群的ABO、Rh、MN、P及Jk(a-b-)血型的分布规律,为献血者招募及科学合理储存血液提供理论依据。方法采用U型96孔微量板法,对献血者血样进行ABO正反定型及Rh、MN、P血型检测,结果可疑者用试管法确认,并进行Jk(a-b-)表型筛查。结果ABO血型基因频率r>p>q,表型分布规律为O>A>B>AB;Rh(D)阴性占0.16%;A2亚型在AB型的检出率高于A型;MN血型的基因频率m>n,表型分布规律为MN>M>N;P血型的基因频率p2>p1,表型分布特征为P2>P1;Jk(a-b-)表型检出率为1∶22161.5。结论韶关地区血型分布以O型所占比例最多,且A型多于B型,A2亚型检出率高,Rh(D)阴性率低,Jk(a-b-)表型更低;应加大O型、A型献血者的招募并相应增加其库存量,特别是要加强Rh(D)阴性和Jk(a-b-)表型献血者的档案管理、Rh(D)阴性血液和Jk(a-b-)血液的冰冻保存工作及Jk(a-b-)人员的自身储血工作。

Distribution of ABO,Rh,MN,P and Jk (a-b-)Blood Groups in Population in Shaoguan Prefecture,Guangdong Province,China

Objective To study the regularity in distribution of ABO, Rh, MN, P and Jk(a-b-) blood groups in Shaoguan Prefecture, Guangdong Province, China, and provide theoretical basis for recruiting blood donors and scientific storage of blood in the region. Methods The blood samples of donors were subjected to forward backward ABO grouping, Rh, MN and P grouping as well as screening of Jk(a-b-) by using U-shaped 96-well microtiter plate, and those with indefinite results were further confirmed by agglutination test in tube. Results The gene frequency of ABO blood group was characterized as r > p > q, and the distribution as O > A > B >AB. Of the test samples, 0. 16% were Rh(D ) negative. The detection rate of A2 subgroup in the samples of group AB was higher than that of group A. The gene frequency of MN blood group was characterized as m>n, and the distribution as MN > M > N. The gene frequency of P blood group was characterized as p2 > p1, and distribution as P2 > P1. The detection rate of Jk(a- b -) blood group was 1 ∶ 22 161. 5. Conclusion Group O was the dominant blood group in Shaoguan Prefecture, and the distribution of group A was higher than that of group B. Compared with those in other regions, the detection rate of A2 subgroup in the region was high, the Rh(D) negative rate was low, and the detection rate of Jk(a-b-) group was remarkably low. More donors of groups O and A should be recruited, and the storage of blood of the two groups should be increased. Especially, the documents of Rh (D ) negative and Jk(a-b-) group donors should be preserved carefully, and the storage of blood from these donors in frozen, as well as the self-blood stock of JJk(a-b-) group donors should be strengthened.