A Diastereoselective Synthesis of Functionalized Tetrahydroindeno[2′,1′,3,4]pyrido[2,1‐a]isoquinolines |
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| Authors: | Arezoo Lazar Manouchehri Anvar Mirzaei Issa Yavari |
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| Affiliation: | 1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran, (phone: +98‐21‐82883465;2. fax: +98‐21‐82883455);3. Department of Chemistry, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran |
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| Abstract: | An effective route to alkyl 9a‐(2,3‐dihydro‐1,3‐dioxo‐1H‐inden‐2‐yl)‐9a,14,14a,14b‐tetrahydro‐14‐oxoindeno2′,1′:3,4]pyrido2,1‐a]isoquinoline‐9‐carboxylates via a diastereoselective one‐pot four‐component reaction of isoquinoline and alkyl prop‐2‐ynoates with two equivalents of indane‐1,3‐dione, in aqueous MeOH at room temperature, is described. |
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| Keywords: | Isoquinoline Alkyl prop‐2‐ynoates Multicomponent reactions Indane‐1 3‐dione |
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