CAST基因研究进展

CAST(calpastatin)基因是钙蛋白酶水解系统成员之一。在一定浓度的钙离子作用下,钙蛋白酶系统主要作用于细胞骨架蛋白、蛋白激酶和磷酸酶,还参与细胞内的信号传递。CAST能促使蛋白质降解减少,导致肌肉增长,还可识别CAPN与钙结合引起的构象变化并与之特异性结合,从而保证钙蛋白酶对底物只进行特定部位的水解。因此,可以通过激活钙蛋白酶或降低钙蛋白酶抑制蛋白的活性来提高肌肉的嫩度,改善肉质。最近的研究表明,CAST基因多态性与家畜的眼肌厚度和眼肌面积存在关联,有望成为提高家畜肉用性能的候选基因。

Progress in CAST Gene

CAST gene was a member of the calpain hydrolytic system.In a certain concentration of calcium ions,calpain system mainly acted on cytoskeletal system protein,protein kinases and phosphatases,and involved in intracellular signaling,also played an important role in myofibrillar updated and tenderization of livestock,poultry after slaughter.Recently many research results indicated that the CAST gene polymorphism was correlated with loineye area.So it was hopeful for CAST to be a candidate gene in raising meat guality.