免疫抑制剂在溃疡性结肠炎中的应用及疗效分析

目的探讨免疫抑制剂对溃疡性结肠炎(UC)的疗效。方法本研究将2004年6月至2008年6月诊治的73例UC患者分为免疫抑制剂治疗(33例)和常规5氨-基水杨酸类药物及激素治疗(40例)两组,观察两组患者的疗效及不良反应。结果免疫抑制剂组中度及重度患者完全缓解率分别为77.8%和83.3%,而常规治疗组分别为41.7%和50.0%,两组患者疗效间差异有统计学意义(P<0.05)。肝、肾功能异常,白细胞减少等不良反应发生率两组间差异均无统计学意义(P>0.05)。结论免疫抑制剂对重症、顽固性UC患者有明显的治疗作用,但必须严密监测其不良反应。

The Application and Therapeutic Effect of Immundepressant on Ulcerative Colitis

Objective To investigate the therapeutic effect of immundepressants on ulcerative colitis（UC）.Methods 73 cases with UC were recuited from June 2004 to June 2008,the cases were divided into two groups,33 patients received therapy with immunodepressant,and the other 40 cases received therapy with aminosalicylic acid.Results The remission rates（CRs）of moderate and severe cases who were received immunodepressant therapy were 77.8%and 83.3%respectively,while,the CRs were 41.7%and 50.0%in aminosalicylic acid therapy group respectively.The difference of CR between the two groups was significant（P〈0.05）.The side effect incidence such as abnormal liver function,hypolekocytosis showed no statistical difference（P〉0.05）.Conclusion Immundepressant is effective on treatment of UC,especially to severe patients and refractory cases,but the side-effect must be monitored.