运动性关节软骨缺损支架材料的选择及其生物相容性

背景：骨软骨支架是用于承载细胞,供细胞黏附、生长、增殖、分化的载体。目的：总结运动性关节软骨缺损支架材料的应用进展及其生物替代材料的生物相容性。方法：以＂关节软骨,生物材料,工程软骨,支架材料,生物相容性＂为中文关键词,以＂tissue enginneering,articular cartilage,scaffold material＂为英文关键词,采用计算机检索维普数据库、PubMed数据库1993-01/2010-11相关文章。纳入与有关修复关节软骨损伤、生物材料、支架材料、生物相容性等相关的文章。以20篇文献为重点对运动性关节软骨缺损修复用的生物材料的生物相容性进行了讨论。结果与结论：天然软骨支架材料因其具有细胞识别信号,故生物相容性好,细胞黏附率高,但力学性能较差。有些人工合成材料生物相容性不理想、亲水性差、对细胞吸附不足,人工合成高分子聚合物生物相容性良好。复合支架利用不同生物材料的优点克制材料的局限性制备理想的复合支架,其混合比例、混合技术还有待进一步研究。目前尚无一种材料完全满足组织工程的要,通过材料制备技术的改进或将几种不同材料的复合,材料的性能会不断的提高。

Selection and biocompatibility of scaffolds for sports articular cartilage defects

BACKGROUND：Bone cartilage scaffold is used for loading cells,as a carrier of cell adhesion,growth,proliferation,differentiation.OBJECTIVE：To summarize the research progress of scaffold materials for sports articular cartilage defects and their biocompatibility as biological substitute materials.METHODS：Using ＂articular cartilage,biological materials,engineering cartilage,scaffolds,biocompatibility＂ as the Chinese key words and ＂tissue engineering,articular cartilage,scaffold material＂ as the English key words,a computer retrieval of VIP database and PubMed database from January 1993 to November 2010 was performed.Articles about the repair of articular cartilage damage,biological materials,scaffold materials,and biocompatibility were included.20 articles focus on the biocompatibility of biomaterials for repairing sports articular cartilage defects.RESULTS AND CONCLUSION：Due to cell recognition signal,natural cartilage scaffolds have good biocompatibility,high cell adhesion rate,but poor mechanical properties.Some synthetic materials is poor in the biocompatibility,hydrophilicity and cell adhesion,synthetic polymers have good biocompatibility.Compound scaffolds utilize the advantages of different biological materials to restrain their limitations,thus becoming an ideal scaffold;the mixing ratio and mixture technology require further studies.There is no ideal scaffold to satisfy tissue engineering requirements,material properties will continue to increase through improvements of material preparation or composite of several different materials.