氧化锆陶瓷材料的生物相容性

背景：已有大量研究表明,氧化锆陶瓷具有优良的生物学性能,但作为牙种植基台的研究在国内还鲜见报道,将其应用于种植牙基台上的生物学性能还需要进一步的验证。目的：评价牙种植基台制作材料氧化锆陶瓷的生物相容性。方法：将氧化锆陶瓷圆形试件固定在Wistar大鼠左颊黏膜表面,右侧用牙胶试件作为对照,使两组试件与颊黏膜紧密贴合但无压迫,术后2周应用大体观察和组织学方法观察口腔黏膜与氧化锆陶瓷材料的生物学反应;将氧化锆陶瓷棒形试件植入Wistar大鼠背部皮下组织内,于植入后1,2,4,8周应用大体观察和组织学方法动态观察皮肤组织与氧化锆陶瓷材料的生物学反应。结果与结论：氧化锆陶瓷圆形试件固定后,大鼠颊黏膜局部组织未见异常,与对照组比较差异无显著性意义;氧化锆陶瓷棒形试件植入第1周可见局部组织轻微红肿,组织切片可见少量炎性细胞,2～8周红肿消退,组织切片见纤维包膜形成并逐渐变薄,到8周时包膜形成致密纤维,未见炎性细胞。提示氧化锆陶瓷材料与口腔黏膜、皮肤及皮下组织具有良好的生物相容性。

Biocompatibility of zirconia ceramic

BACKGROUND：Previous experiments demonstrate that zirconia ceramic has excellent biological features.However,the research regarding zirconia ceramic material made into abutments of dental implants in China,especially their biocompatibility,are poorly understood.OBJECTIVE：To evaluate the biocompatibility of zirconia ceramic as the abutments of dental implants.METHODS：Zirconia ceramic round specimens were fixed in left buccal mucosal surface of Wistar rats,while the right with gutta-percha specimens as a control,two groups of specimens tightly attached to buccal mucosa without oppression.Gross observations and histological methods were applied to observe the biological response between oral mucosa and zirconia ceramic materials at 2 weeks after operation;zirconia ceramic rod specimens was implanted into dorsal subcutaneous tissue of Wistar rats,gross observation and histological methods were used to dynamically observe biological response between skin tissue and zirconia ceramic materials at 1,2,4,8 weeks after implantation.RESULTS AND CONCLUSION：After zirconia ceramic round specimens were fixed,no abnormal reactions of local tissue were observed in rat buccal mucosa,and there was no significant difference compared with the control group.At 1 week after zirconia ceramic rod specimens was implanted,local tissue was found to be slightly red and swollen,and the biopsies showed a few of inflammatory cells.2-8 weeks later,redness and swelling had gone down,fibrous capsule was formed and became thinner gradually in tissue section.At 8 weeks,the capsule became dense fibrous with no inflammatory cells.There is a good biocompatibility between zirconia ceramic material and oral mucosa,skin or subcutaneous tissue.