| 5种缬草素类成分电喷雾质谱裂解规律研究 |
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| 引用本文： | 王春国,刘勇,石晋丽,肖瑶,史淑宁,侯文慧,王子健.5种缬草素类成分电喷雾质谱裂解规律研究[J].中国中药杂志,2013,38(4):578-584. |
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| 作者姓名： | 王春国 刘勇 石晋丽 肖瑶 史淑宁 侯文慧 王子健 |
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| 作者单位： | 北京中医药大学,北京,100029 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2012ZX09102-201-018);北京中医药大学研究生项目(2011jyb22x5039) |
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| 摘 要： | 目的:探讨缬草素类成分中的单烯型(二氢缬草素)、二烯型(缬草素,乙酰缬草素)和四烯型(baldrinal,homobaldrinal)5种化合物在电喷雾多级质谱下的裂解规律.方法:采用电喷雾离子化源(Electron Spray Ionization,ESI源)多级质谱,极性检出正离子检测模式(MS+)进行多级碎片解析.结果:归纳总结了单烯型、双烯型和四烯犁3类缬草索成分在正离子模式的电喷雾多级质谱裂解规律.结论:该类化合物有着较强的裂解规律,可用于缬草素类化合物的快速结构鉴定、定量分析和药代动力学研究.
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| 关 键 词： | 缬草素类成分 电喷雾多级质谱 质谱裂解规律 |
| 收稿时间： | 2012/10/16 0:00:00 |
Mass spectrum characterization of five valepotriates by electrospray ionization tandem mass spectrometry |
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| WANG Chun-guo,LIU Yong,SHI Jin-li,XIAO Yao,SHI Shu-ning,HOU Wen-hui and WANG Zi-jian.Mass spectrum characterization of five valepotriates by electrospray ionization tandem mass spectrometry[J].China Journal of Chinese Materia Medica,2013,38(4):578-584. |
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| Authors: | WANG Chun-guo LIU Yong SHI Jin-li XIAO Yao SHI Shu-ning HOU Wen-hui and WANG Zi-jian |
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| Affiliation: | Beijing University of Chinese Medicine, Beijing 100029, China;Beijing University of Chinese Medicine, Beijing 100029, China;Beijing University of Chinese Medicine, Beijing 100029, China;Beijing University of Chinese Medicine, Beijing 100029, China;Beijing University of Chinese Medicine, Beijing 100029, China;Beijing University of Chinese Medicine, Beijing 100029, China;Beijing University of Chinese Medicine, Beijing 100029, China |
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| Abstract: | |
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| Keywords: | valepotriates electrospray ionization tandem mass spectrometry fragmentation pathways |
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