C-erbB-2蛋白在子宫内膜病变中的表达及临床意义

目的研究C-erbB-2蛋白在子宫内膜病变中的表达规律度其在子宫内膜癌的发生、预后评估的临床价值。方法用免疫组化法（S-P）检测增生期、分泌期正常子宫内膜各15例作为对照组。子宫内膜增殖症30例、非典型增生30例、子宫内膜癌高、中、低分化各30例，共150例作为实验组，观察C-erbB-2蛋白及雌激素受体（ER）、孕激素受体（PR）在正常子宫内膜及不同内膜病变中的阳性表达。结果C-erbB-2蛋白和ER、PR在子宫内膜增殖症、非典型增生中阳性表达与对照组相比无统计学差异（P〉0．05）。在子宫内膜癌中，C-erbB-2蛋白的阳性表达明显升高，有统计学意义（P〈0．01）；在子宫内膜癌中ER、PR阳性表达降低。与对照组比较有意义。C-erbB-2蛋白阳性表达率与临床分期（P〈0．05）、组织分化程度（P〈0．05）、淋巴转移（P〈0．01）和ER、PR（P〈0．05）有关。结论C-erbB-2蛋白、ER、PR与子宫内膜癌的发生密切相关，C-erbB-2蛋白表达增加、ER及PR表达减少提示子宫内膜病变恶性程度高，且预后不良。

Expression of Protein C-erbB-2 in endometrial diseases and clinical significance

Objective] To investigate the expression of Protein C-erbB-2 and estrogen receptor(ER), progesterone receptor (PR) in Endometrial Diseases and its clinical significance for the incidence of endometrial carcinoma and evaluation for prognosis. Method] Experimental group: 150 cases including 90 of endometrial carcinoma, 30 of edometrial hyperlpasia, 30 of atypical proliferation. Control group: 30 cases including 15 of proliferative endometrium and 15 of secretory endometrium. Detect the expression of ER, PR, Protein C-erbB-2 in these cases. Results] Expression of protein C-erbB-2 and ER ?PR in endometrial hyperlpasia atypical proliferation have no statistical significance between the control group and experimental group (P >0.05). The expression of protein C-erbB-2 obviously increase in endometrial carcinoma and there is significance (P <0.01) compared with control group and The expression of ER (P<0.01) and PR (P <0.05) decrease in endometrial carcinoma compared with control group. The positive rate of Protein C-erbB-2 is correlation with the clinical phase (P <0.05), grade of cellular differentiation(P<0.05) and ER, PR (P <0.05). Conclusion] protein C-erbB-2, ER and PR are related to the incidence of endometrial carcinoma. The over expression protein C-erbB-2 indicates a poor prognosis of patients with endometrial carcinoma.