| 一氧化氮、SOD与腰椎间盘突出症的关系 |
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| 引用本文： | 冯德荣,黄迪南.一氧化氮、SOD与腰椎间盘突出症的关系[J].中国组织工程研究与临床康复,1998(10). |
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| 作者姓名： | 冯德荣 黄迪南 |
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| 作者单位： | 深圳市宝安区人民医院(冯德荣)，广东医学院生化教研室(黄迪南) |
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| 摘 要： | 目的：探讨一氧化氮（ＮＯ）和超氧化物歧化酶（ＳＯＤ）在腰椎间盘突出症（ＬＩＤＰ）发病中的作用和意义。方法：分别用微盘测定法和亚硝酸盐形成法测定２０例ＬＩＤＰ患者及１８例正常人血浆ＮＯ及ＳＯＤ含量。结果：ＬＩＤＰ患者血浆ＮＯ水平比正常人显著增高（Ｐ＜０．０１），ＮＯ为：６．３９±３．６５μｍｏｌ／Ｌ与３．４８±０．９５μｍｏｌ／Ｌ；ＬＩＤＰ患者血浆ＳＯＤ水平比正常人增高，但无统计学意义（Ｐ＞０．０５），ＳＯＤ为：３７．５０±１６．３４ＮＵ／ｍｌ与３２．９３±１７．７７ＮＵ／ｍｌ。结论：ＬＩＤＰ的发病与自由基损伤有关。清除自由基、提高ＳＯＤ活性可能是治疗ＬＩＤＰ的方法之一
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| 关 键 词： | 一氧化氮 氧化物歧化酶 腰椎间盘突出症 自由基 |
Relationship of nitric oxide and superoxide dismutase with prolapse of lumbar InIervertebral Disc |
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| Affiliation: | (Feng Derong,Huang Dinan Depertmet of Rehabilitation Medicime,The Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001) |
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| Abstract: | Objective To investigate the levels of nitric Oxide(NO)and superoxide dismutase(SOD)in prolapse of lumbar intervertebral Disc(PLID)patients.Methods The plasma levels of NO and activity of SOD in the patients with PLID,were determined by means of microwell plate spectrophotometry and nitrite Formation methods.Results In the PLID patients,comparing with the control group,the plasma concentration of NO increased significantly(P<0.01),and the activities of SOD in increased,but not significantly(P>0.05).Conclusion The PLID were associated with free radical.One of the therapeutic method on the PLID may be by the reduing free radicals and the increasing the activity of SOD. |
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| Keywords: | NO SOD PLID Free radical |
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