Immunopathological correlation with lymph node metastasis in squamous cell carcinoma of larynx and pharynx

In this study, the commonest malignancy was supraglottic carcinoma (12 of 17 cass). Mostly (94%) our patients were males. Histologically moderate or poorly differentiated squamous cell carcinoma was the commonest tumour. Thirteen of 17 (76%) cases had secondaries in neck and bilateral secondaries were seen only in supraglottic carcinomas. Cases with post cricoid involvement (absent laryngeal crepitus) had metastasis in neck in 90% of cases. DIMCB and PHA skin reactivity did not reveal any difference between the cases with secondary tumours and those without secondaries in neck (P>0.05). Absolute lymphocyte count (A.L.C.) was found to be significantly increased in the former group (P<0.05).