| 反相乳液聚合制备阿霉素磁性抗癌毫微粒 |
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| 引用本文： | 沈海霞,黄兴华,许小平.反相乳液聚合制备阿霉素磁性抗癌毫微粒[J].福州大学学报(自然科学版),2007,35(1):121-125. |
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| 作者姓名： | 沈海霞 黄兴华 许小平 |
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| 作者单位： | 福州大学化学化工学院,福建,福州,350002 |
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| 基金项目： | 福建省科技计划
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SRTP资助项目 |
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| 摘 要： | 以阿霉素为模型药物,Fe3O4为磁核,乙烯吡咯烷酮(NVP)为载体,通过反相乳液聚合法制备了阿霉素磁性抗癌毫微粒,并对影响阿霉素磁性毫微粒大小及粒径分布的因素进行了考察.环境扫描电镜表明,最佳制备条件下制得的毫微粒外观光滑,大小均匀;激光光散射测定表明该产物平均粒径为500 nm,粒径分布系数0.23,呈单分散分布;红外光谱测试证明本实验所制备的毫微粒是由阿霉素、Fe3O4和聚乙烯吡咯烷酮共同组成.
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| 关 键 词： | 阿霉素 聚乙烯吡咯烷酮 磁性毫微粒 反相乳液聚合 |
| 文章编号： | 1000-2243(2007)01-0121-05 |
| 修稿时间： | 2004年6月3日 |
The preparation of doxorubicin-loaded magnetic microsphere by inverse emusion polymerization |
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| SHEN Hai-xi,HUANG Xing-hu,XU Xiao-ping.The preparation of doxorubicin-loaded magnetic microsphere by inverse emusion polymerization[J].Journal of Fuzhou University(Natural Science Edition),2007,35(1):121-125. |
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| Authors: | SHEN Hai-xi HUANG Xing-hu XU Xiao-ping |
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| Affiliation: | (College of Chemistry and Chemical Engineering,Fuzhou University,Fuzhou,Fujian 350002,China) |
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| Abstract: | Doxorubicin-loaded magnetic nanoparticles,using doxorubicin as model drug,Fe3O4 as core and vinylpyrrolidone as matix material,were prepared by inverse emulsion polymerization in this paper.And the effect factors on the size and the size distribution of doxorubicin-loaded magnetic nanoparticles were discussed.The optimal prepared doxorubicin-loaded magnetic nanoparticles have a smooth spherical surface with average size 500nm and a narrow size distribution.And IR results indicated that the magnetic nanoparticles consists of doxorubicin,Fe3O4 and polyvinylpyrrolidone. |
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| Keywords: | doxorubicin polyvinylpyrrolidone magnetic nanoparticle inverse emusion polymerization |
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