| 玉竹提取物B对人食管癌细胞Eca-109增殖与凋亡的影响 |
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| 引用本文： | 张岚,杜亚明,王中彬.玉竹提取物B对人食管癌细胞Eca-109增殖与凋亡的影响[J].山东医药,2010,50(18):3-4. |
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| 作者姓名： | 张岚 杜亚明 王中彬 |
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| 作者单位： | 辽宁医学院附属第一医院,辽宁锦州,121001 |
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| 基金项目： | 辽宁省教育厅科研计划资助项目，辽宁省锦州市科学技术计划资助项目 |
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| 摘 要： | 目的观察玉竹提取物B（EB-PAOA）对人食管癌细胞Eca-109增殖与凋亡的影响。方法将体外培养的Eca-109细胞与不同浓度的EB-PAOA共育,采用MTT法检测Eca-109细胞增殖抑制率,采用流式细胞仪检测Eca-109细胞凋亡率。结果随着EB-PAOA浓度增大、作用时间延长,Eca-109细胞的增殖抑制率逐渐升高（P均〈0.05）,呈时间、剂量依赖性;随着EB-PAOA浓度增加,Eca-109细胞凋亡率逐渐增加,呈一定浓度依赖性（P均〈0.05）。结论EB-PAOA能够抑制人食管癌细胞Eca-109的增殖,并诱导其凋亡。
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| 关 键 词： | 玉竹 食管肿瘤 食管癌细胞 细胞凋亡 |
Effect of extract B of polygonatum odoratum on human esophageal cancer Eca-109 cells proliferation and apoptosis |
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| ZHANG Lan,DU Ya-ming,WANG Zhong-bin.Effect of extract B of polygonatum odoratum on human esophageal cancer Eca-109 cells proliferation and apoptosis[J].Shandong Medical Journal,2010,50(18):3-4. |
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| Authors: | ZHANG Lan DU Ya-ming WANG Zhong-bin |
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| Affiliation: | ZHANG Lan,DU Ya-ming,WANG Zhong-bin(First Affiliated Hospital of Liaoning Medical College,Jinzhou 121001,P.R.China) |
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| Abstract: | Objective To observe the effect of extract B of polygonatum odoratum(EB-PAOA)on human esophageal cancer Eca-109 cells proliferation and apoptosis.Methods Eca-109 Cells were cultured with different concent ration of EB-PAOA in vitro.The proliferation inhibiting rate was detected by MTT method.The apoptotic rate was detected by flow cytometer.Results Eca-109 cell proliferation rate gradually increased with the EB-PAOA concentration and time increases,with EB-PAOA concentration,Eca-109 cell apoptosis increased... |
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| Keywords: | polygonatum odoratum esophageal neoplasm esophageal cancer cell apoptosis |
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