| 盐酸阿夫唑嗪的合成工艺研究 |
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| 引用本文： | 徐静,何湛,宋宏锐.盐酸阿夫唑嗪的合成工艺研究[J].精细化工中间体,2010,40(3):40-43. |
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| 作者姓名： | 徐静 何湛 宋宏锐 |
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| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 摘 要： | 以6,7-二甲氧基-2,4-(1H,3H)-喹唑啉二酮为原料,改进氯代、氨解的条件,制备了中间体2-氯-4-氨基-6,7-二甲氧基喹唑啉(4);以化合物4、2-四氢呋喃甲酸和3-氯丙胺为原料,优化缚酸剂及其加入方式,制得目标产物盐酸阿夫唑嗪(1),总收率达到36.84%。目标化合物的结构经GC-MS、1HNMR确证。该工艺路线采用低成本原料,简单可行,适合于工业化生产。
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| 关 键 词： | 盐酸阿夫唑嗪 良性前列腺增生 合成工艺 |
Improved Synthesis of Alfuzosin Hydrochloride |
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| XU Jing,HE Zhan,SONG Hong-rui.Improved Synthesis of Alfuzosin Hydrochloride[J].Fine Chemical Intermediates,2010,40(3):40-43. |
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| Authors: | XU Jing HE Zhan SONG Hong-rui |
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| Affiliation: | (School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | Alfuzosin hydrochloride was synthesized starting from 6,7-dimethoxyquinazoline-2,4-（1H,3H） dione via intermediate 2-chloro-4-amino-6,7-dimethoxyquinazoline in an overall yield of 36.84%.The structure of the target compound was characterized with GC-MS and 1H NMR. |
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| Keywords: | alfuzosin hydrochloride benign prostatic process improvement |
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