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| HPLC Method for the Determination of Tamsulosin Hydrochloride in Sustained Release Tablets | |
| 作者姓名： | 齐美玲 王鹏 耿颖姝 顾峻岭 |
| 作者单位： | [1]DepartmentofChemistry,SchoolofScience,BeijingInstituteofTechnology,Beijing100081,China [2]SchoolofPharmaceuticalEngineering,ShenyangPharmaceuticalUniversity,Shenyang,Liaoning110015,China [3]ShenyangPharmtechInstituteofPharmaceuticals,Shenyang,Liaoning110015,China |
| 摘 要： | The development and validation of an isocratic high performance liquid chromatographic method is de-scribed for the determination of tamsulosin hydrochloride in sustained release tablets. The determination was per-formed on a Diamonsil BDS C18 column with a mobile phase consisting of a mixture of acetonitrile, methanol and 0.5% phosphoric acid solution (20:30:50, V/V/V) at a flow rate of 1.0 mL/min. UV detection was made at 274 nm. The linear range for tamsulosin hydrochloride was 0.81 - 8.10μg/mL. The mean recovery was 99.8%(SR = 0.7 %, n = 9), and the precision was found to be 0.45 % ( n = 9). The proposed method can be used for routine analysis of tamsulosin hydrochloride in sustained release tablets. |
| 关 键 词： | 高效液相色谱分析 HPLC 药物分析 前列腺增生 治疗 缓释剂 盐酸坦索罗辛 |
| 收稿时间： | 2002/4/17 0:00:00 |
HPLC Method for the Determination of Tamsulosin Hydrochloride in Sustained Release Tablets |
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| QI Mei ling,WANG Peng,GENG Ying shu and GU Jun ling.HPLC Method for the Determination of Tamsulosin Hydrochloride in Sustained Release Tablets[J].Journal of Beijing Institute of Technology,2003,12(2):194-197. | |
| Authors: | QI Mei ling WANG Peng GENG Ying shu and GU Jun ling |
| Affiliation: | 1. Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, China 2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning 110015, China 3. Shenyang Pharmtech Institute of Pharmaceuticals, Shenyang, Liaoning 110015, China |
| Abstract: | The development and validation of an isocratic high performance liquid chromatographic method is described for the determination of tamsulosin hydrochloride in sustained release tablets. The determination was performed on a Diamonsil BDS C18 column with a mobile phase consisting of a mixture of acetonitrile, methanol and 0.5% phosphoric acid solution (20∶30∶50,V/V/V) at a flow rate of 1.0 mL/min. UV detection was made at 274 nm. The linear range for tamsulosin hydrochloride was 0.81-8.10 μg/mL. The mean recovery was 99.8% (SR=0.7%, n=9), and the precision was found to be 0.45% (n=9). The proposed method can be used for routine analysis of tamsulosin hydrochloride in sustained release tablets. |
| Keywords: | HPLC tamsulosin hydrochloride sustained release tablets |
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