缺血性脑卒中患者颈动脉斑块性质与同型半胱氨酸、血脂水平的相关性分析

目的研究缺血性脑卒中与同型半胱氨酸（HCY）及血脂水平的关系，并探讨不同斑块性质与同型半胱氨酸和血脂代谢的相关性。方法选择湖北省十堰市太和医院通过彩色多普勒技术检测出伴有颈动脉斑块的脑卒中患者162例，根据斑块分型，易损斑块73例，稳定斑块89例，并选择健康体检者70例，检测其血脂及同型半胱氨酸水平。结果脑卒中患者胆固醇（TC）、低密度脂蛋白（LDL_C）及同型半胱氨酸（t-HCY）水平较对照组明显升高（P〈0．05）；与稳定斑块组比较，易损斑块组血浆胆固醇（TC）、低密度脂蛋白（LDL-C）及同型半胱氨酸（t-HCY）水平升高（P〈0．05）。结论颈动脉粥样硬化斑块的形成与血脂水平异常密切相关，而高水平的同型半胱氨酸可影响血脂代谢并且是脑卒中发病的一个重要危险因素，个体优化调脂及逆转同型半胱氨酸水平治疗在脑卒中的二级预防中具有重要意义。

Relationship between carotis plaque's character and homocysteine, blood fat in cerebral arterial thrombosis patients

Objective To explore the relationship between cerebral arterial thrombosis and homocys- teine, bood fat, and investigate the associativity between different carotis plaque＇s character and the metabolism of homocysteine,blood fat. Methods 162 cerebral arterial thrombosis patients with carotis plaque were selected by transcranial doppler in Taihe Hospital of Hubei province, and divided into different groups according to plaque＇s character（unstabilized plaque group with 73 cases, stabilized plaque group with 89 cases and normal control group with 70 cases）. The concentrations of blood fat and homocysteine were detected in all cases. Re- sults The concentrations of cerebral arterial thrombosis patients＂ cholesterol （TG）, low density lipoprotein （LDC-C）, homocysteic acid （t-HCY） significantly increased compared with normal control group （P〈0. 05）. The concentrations of TG, LDC-C and t-HCY in unstabilized plaque group also were higher than those in stabi- lized plaque group（P〈0. 05）. Conclusions There is an intimate relationship between the formation of carotis atherosclerotic plaque and the concentration of blood fat. The high concentration of t-HCY might impact lipid metabolism, and it also is a very important risk factor of cerebral arterial thrombosis＂ occurrence. The treatment of adjusting blood fat and reversing homocysteic acid is important for the stroke secondary prevention.