口腔颌面部鳞癌SNCG、MMP-9的表达及其临床意义

目的：探讨神经突触核蛋白-γ（synuclein gamma，SNCG）及基质金属蛋白酶-9（matrix metalloproteinase-9，MMP-9）在鳞状细胞癌及癌旁组织的表达，分析其与肿瘤的临床及病理特征相关性。方法：采用免疫组化 EnVision 二步法检测150例鳞状细胞癌及癌旁组织中 SNCG 及 MMP-9的表达。结果：口腔颌面部鳞癌组织中的 SNCG 及 MMP-9的阳性率分别为78．0％（117/150）及68．68％（103/150），而癌旁组织中 SNCG及 MMP-9的阳性率分别为8．0％（11/150）及14．0％（21/150），均有显著性差异（P＜0．001）。低分化、中分化肿瘤的 SNCG及 MMP-9的表达阳性率显著高于高分化肿瘤中的阳性率（P＜0．001），然而低分化与中分化肿瘤之间 SNCG及 MMP-9的表达阳性率无显著性差异（P＞0．05）。肿瘤分期分析结果显示，Ⅲ～Ⅳ期SNCG及 MMP-9的表达阳性率显著高于Ⅰ～Ⅱ期，有显著性差异（SNCG：χ^2＝4．20，P＝0．041；MMP-9：χ^2＝26．66，P＝0．000）。转移的肿瘤组织中的SNCG及MMP-9的表达阳性率分别为90．77％和93．85％，高于其在无转移的肿瘤组织表达阳性率，有显著性差异（SNCG：χ^2＝10．09，P＝0．001；MMP-9：χ^2＝33．80，P＝0．000）结论：SNCG、MMP-9在与口腔颌面部鳞癌中呈现高表达，与肿瘤的病理与临床分级、分期呈正相关，提示检测口腔颌面部鳞癌组织中 SNCG及 MMP-9的表达可以为肿瘤的病情进展和预后判断提供依据。

Expression of SNCG and MMP-9 in oral and maxillofacial carcinoma and its clinical significance

Objective：To analyze the correlation between synuclein gamma （SNCG）and matrix metalloproteinase-9 （MMP-9）and the clinicopathological features of tumor,we investigated the expression of SNCG and MMP-9 in oral and maxillofacial carcinoma and its adjacent tissues.Methods：Immunohistochemistry method was used to detect the expression of SNCG and MMP-9 in oral and maxillofacial carcinoma and its adjacent tissues.Results：The incidence rate of SNCG and MMP-9 in oral and maxillofacial carcinoma was 78.0% （1 17/150）and 68.68%（103/150）,respectively.While that of SNCG and MMP-9 in its adjacent tissues was 8.0%（1 1/150） and 14.0%（21/150）,respectively.There were significantly differences in SNCG and MMP-9 between them（P 〈0.001）.The inci-dence rates of SNCG and MMP-9 were higher in poorly or medium differentiated （P〈0.001 ）.However,the expression of SNCG and MMP-9 between poorly differentiated and well differentiated carcinoma had no significant difference.According to stages,the incidence rates of SNCG and MMP-9 in Ⅲ-Ⅳ period were significantly higher than those inⅠ-Ⅱ period,and there were significant difference （SNCG：χ^2 =4.20,P=0.041;MMP-9：χ^2 =26.66,P=0.000）.The expression of SNCG and MMP-9 in metastatic tumor were higher （SNCG：90.77%;MMP-9：93.85% ）than that in non-metastatic tumor （SNCG：68.24%;MMP-9：49.41%）,and there were significant difference（SNCG：χ^2 =10.09,P=0.0014;MMP-9：χ^2 =33.80,P=0.000）.Conclusions：The excessive expression of SNCG and MMP-9 in oral and maxillofacial carcinoma,which was positively associated with the pathologic process,differentiation degree of carcinoma,and TNM stages of tumor.The expression of SNCG and MMP-9 are expected to be the marker in the tumor of oral and maxil-lofacial carcinoma for the judgment of advancement and prognosis.