自噬与炎症性肠病关系的研究进展

自噬是由自噬相关基因（autophagy-related genes, ATGs）调控细胞，使细胞内老化、损伤的细胞物质被送到溶酶体内降解和再循环利用，从而维持细胞稳态。炎症性肠病（inflammatory bowel disease, IBD）是一种自身免疫性疾病，而自噬选择性地以细胞内病原体为目标进行破坏的能力被认为是先天免疫反应的一个关键方面。遗传研究表明，几种自噬相关基因在IBD发病机制中具有临床相关性。本文将阐述自噬在IBD中的作用及其临床相关的最新进展，以及以自噬为靶点的IBD治疗策略。

Research progress of the relationship between autophagy and inflammatory bowel disease

Autophagy is regulated by autophagy-related genes (ATGs), so that the aged and damaged cellular substances in cells are sent to lysosomes for degradation and recycling, thereby maintaining cellular homeostasis. Inflammatory bowel disease (IBD) is an autoimmune disease, and the ability of autophagy to selectively target intracellular pathogens for destruction is considered a key aspect of the innate immune response. Genetic studies suggest that several autophagy-related genes are clinically relevant in the pathogenesis of IBD. This article will describe the role of autophagy in IBD and the latest advances in its clinical relevance, as well as autophagy-targeted therapeutic strategies for IBD.