| 甲状腺髓样癌的CGRP原位杂交检测 |
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| 引用本文： | 孙青,鹿伟,张传森,吴彩志,高钟禹,孙德刚.甲状腺髓样癌的CGRP原位杂交检测[J].诊断病理学杂志,2000,7(3):199-200,I053. |
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| 作者姓名： | 孙青 鹿伟 张传森 吴彩志 高钟禹 孙德刚 |
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| 作者单位： | 1. 第一军医大学病理学博士研究生
2. 山东省千佛山医院病理科济南 250014 |
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| 基金项目： | 本课题受山东省卫生厅医药卫生科研基金资助 |
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| 摘 要： | 目的 ＣＧＲＰ在甲状腺髓样癌表达的意义及病理诊断和鉴别诊断的价值。方法 选择甲状腺髓样癌１０例，乳头状癌５例，滤泡癌５例，未分化癌５例，滤泡型腺瘤５例，行地高辛标记ＣＧＲＰ ｃＤＮＡ探针原位杂交检测。结果 １０例髓样癌和１例滤泡性腺癌呈强阳性；其它均呈阴性。结论 ＣＧＲＰ原位杂交分析是甲状腺髓样癌有价值的诊断和鉴别诊断方法。
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| 关 键 词： | 甲状腺髓样癌 CGRP 原位杂交 鉴别诊断 |
| 文章编号： | 1007-8096(2000)03-0199-02 |
An immunohistochemical study of p21rss protein in thyroid tumors |
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| Sun Qing,Lu Wei,Zhang Chuansen,et al..An immunohistochemical study of p21rss protein in thyroid tumors[J].Chinese Journal of Diagnostic Pathology,2000,7(3):199-200,I053. |
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| Authors: | Sun Qing Lu Wei Zhang Chuansen |
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| Affiliation: | Sun Qing,Lu Wei,Zhang Chuansen,et al. Department of Pathology,Qian-Fo-Shan Hospital,Jinan 250014 |
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| Abstract: | Objective To evaluate the significance and practical value of p21ras protein expression in the diagnosis of thyroid tumors. Methods A monoclonal antibody p21ras and LSAB immunohistochemical methods were used to detect its expression in 10 cases of thyroid adenoma, 10 atypical adenoma, 20 papillary carcinoma, 20 follicular carcinoma, 10 medullary carcinoma and 10 undifferentiated carcinoma. Results Positive cells of p21ras were found in thyroid carcinomas, adenomas and normal thyroid tissues, but there was a significant difference of the staining intensity between thyroid adenomas and carcinomas. Conclusion Over-expression of p21ras is closely related to thyroid tumorgenesis and can be used as a useful marker in differential diagnosis of thyroid tumors. |
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| Keywords: | Thyroid tumors p21ras Immunohistochemistry Differential diagnosis |
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