鞘磷脂类信号通路与动脉粥样硬化的研究进展

动脉粥样硬化是临床常见的冠心病和脑梗死等缺血性心脑血管疾病的主要病理基础,其病因复杂,发病机制尚未完全阐明。近年来,越来越多的研究显示鞘磷脂类信号通路可通过调节脂代谢、炎症和血管内皮功能等影响动脉粥样硬化的发生发展。文章综述了鞘磷脂类信号通路关键分子鞘磷脂、神经酰胺和1-磷酸鞘氨醇与动脉粥样硬化的关系,旨在为防治疾病提供新思路。

Research progress on the relationship between sphingomyelin signaling pathway and atherosclerosis

Atherosclerosis(As) is the main pathological basis of ischemic cardiovascular and cerebrovascular diseases such as coronary heart disease and cerebral infarction. Its etiology is complicated and the pathogenesis has not been fully clarified. In recent years, more and more studies revealed that sphingomyelin signaling pathway can affect the occurrence and development of atherosclerosis by regulating lipid metabolism, inflammation and vascular endothelial function. This paper reviews the relationship between sphingomyelin, ceramide and sphingosine-1-phosphate, the key molecules of sphingomyelin signaling pathway, and atherosclerosis in order to provide new ideas for the prevention and treatment of As.