| 羧甲基化白及多糖-壳聚糖载姜黄素聚电解质复合膜的制备及其表征 |
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| 引用本文： | 王玉蓉,冯斌,巨佳,成黎霏,王济,顾宜,王晓娟.羧甲基化白及多糖-壳聚糖载姜黄素聚电解质复合膜的制备及其表征[J].中草药,2020,51(4):978-985. |
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| 作者姓名： | 王玉蓉 冯斌 巨佳 成黎霏 王济 顾宜 王晓娟 |
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| 作者单位： | 陕西中医药大学, 陕西 咸阳 712046;军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔生物工程技术研究中心, 空军军医大学口腔医院药剂科, 陕西 西安 710032,军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔生物工程技术研究中心, 空军军医大学口腔医院药剂科, 陕西 西安 710032,军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔生物工程技术研究中心, 空军军医大学口腔医院药剂科, 陕西 西安 710032,军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔生物工程技术研究中心, 空军军医大学口腔医院药剂科, 陕西 西安 710032,军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔生物工程技术研究中心, 空军军医大学口腔医院药剂科, 陕西 西安 710032,军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔生物工程技术研究中心, 空军军医大学口腔医院药剂科, 陕西 西安 710032,军事口腔医学国家重点实验室, 口腔疾病国家临床医学研究中心, 陕西省口腔生物工程技术研究中心, 空军军医大学口腔医院药剂科, 陕西 西安 710032 |
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| 基金项目： | 陕西省中医管理局中医药科研课题（JCMS053） |
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| 摘 要： | 目的制备羧甲基化白及多糖-壳聚糖载姜黄素聚电解质复合膜,进行处方、制备工艺优化,并进行质量评价。方法对白及多糖进行羧甲基化修饰,羧甲基化白及多糖与壳聚糖通过静电结合形成水不溶性复合物。以姜黄素为模型药物,采用溶剂挥发法制备载药聚电解质复合膜;通过单因素和正交设计法进行处方优化,用扫描电子显微镜和显微红外光谱对复合膜的形态和结构进行表征。结果最优处方为羧甲基白及多糖117 mg,壳聚糖233 mg,甘油含量为25%,姜黄素为20 mg。平均厚度为(74.0±2.0)μm,载药量为95.41%,体外累积释放率可达93.78%。结论优化条件下制备的载药复合膜外观光滑平整,分布均匀,载药量和累积释放度良好。
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| 关 键 词： | 羧甲基化 白及多糖 壳聚糖 姜黄素 聚电解质复合膜 处方优化 质量评价 溶剂挥发法 正交设计 |
| 收稿时间： | 2019/10/1 0:00:00 |
Carboxymethyl Bletilla striata polysaccharide-chitosan@curcumin polyelectrolyte complex films: Preparation and characterization |
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| WANG Yu-rong,FENG Bin,JU Ji,CHENG Li-fei,WANG Ji,GU Yi and WANG Xiao-juan.Carboxymethyl Bletilla striata polysaccharide-chitosan@curcumin polyelectrolyte complex films: Preparation and characterization[J].Chinese Traditional and Herbal Drugs,2020,51(4):978-985. |
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| Authors: | WANG Yu-rong FENG Bin JU Ji CHENG Li-fei WANG Ji GU Yi and WANG Xiao-juan |
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| Affiliation: | Shaanxi University of Chinese Medicine, Xianyang 712046, China;State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, Hospital of Stomatology, The Fourth Military Medical University, Xi''an 710032, China,State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, Hospital of Stomatology, The Fourth Military Medical University, Xi''an 710032, China,State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, Hospital of Stomatology, The Fourth Military Medical University, Xi''an 710032, China,State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, Hospital of Stomatology, The Fourth Military Medical University, Xi''an 710032, China,State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, Hospital of Stomatology, The Fourth Military Medical University, Xi''an 710032, China,State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, Hospital of Stomatology, The Fourth Military Medical University, Xi''an 710032, China and State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, Hospital of Stomatology, The Fourth Military Medical University, Xi''an 710032, China |
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| Abstract: | |
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| Keywords: | carboxymethylation Bletilla striata polysaccharide chitosan curcumin polyelectrolyte complex films formulation optimization quality evaluation solvent evaporation method orthogonal design |
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