| 复方奥硝唑酊剂的制备及质量控制 |
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| 引用本文： | 彭婕,卢岩,谈恒山.复方奥硝唑酊剂的制备及质量控制[J].中国药师,2006,9(2):126-128. |
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| 作者姓名： | 彭婕 卢岩 谈恒山 |
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| 作者单位： | 南京大学医学院附属鼓楼医院药剂科临床药学室,南京,210008 |
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| 摘 要： | 目的:研制复方奥硝唑酊剂并对制剂进行质量控制。方法:以奥硝唑和西米替丁为主药,采用HPLC法建立该制剂的质控指标,并考察制剂的刺激性和稳定性。结果:奥硝唑的平均回收率为99．81％,西米替丁的平均回收率为100．77％。结论:该制剂配方合理,制备工艺和质量控制方法简便可行,无刺激性,可用于临床。
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| 关 键 词： | 奥硝唑 西米替丁 酊剂 高效液相色谱法 质量控制 |
| 文章编号： | 1008-049X(2006)02-0126-03 |
| 收稿时间： | 2005-07-18 |
| 修稿时间： | 2005-09-12 |
Preparation and Quality Control of Compound Ornidazole Tincture |
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| Peng Jie,Lu yan,Tan Hengshan.Preparation and Quality Control of Compound Ornidazole Tincture[J].China Pharmacist,2006,9(2):126-128. |
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| Authors: | Peng Jie Lu yan Tan Hengshan |
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| Affiliation: | Department of clinical Pharmacy, Affiliated Drum Tower Hospital, Medical College, Nanjing University Nanjing 210008, P. R. China |
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| Abstract: | Objective: To prepare the compound ornidazole tincture and study the quality control of this preparation. Method: Ornidazole and cimetidine were used as main ingredients in compound ornidazole tincture. This preparation was under quality control by the method of HPLC and inspected the irritation and stability of this preparation. Result: The average recovery of ornidazole and cimifi-dine were 99. 81% and 100. 77% respectivery. Conclusion: The pharmaceutical formulation of compound ornidazole tincture is reasonable and the method of preparation and quality control are simple. It can be used for clinic practise, without irritation. |
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| Keywords: | Ornidazole Cimetidine Tincture HPLC Quality Control |
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