Engineering of pharmaceutical materials: an industrial perspective |
| |
| Authors: | Chow Kwok Tong Henry H Y Lum Susan Chow Albert H L |
| |
| Affiliation: | Pharmaceutical Development Services, Patheon, Inc., 2100 Syntex Court, Mississauga, Ontario, Canada L5N 7K9. kwok.chow@patheon.com |
| |
| Abstract: | Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
