| Analysis of CD4^＋CD25^＋ Regulatory T Cells and Foxp3 mRNA in the Peripheral Blood of Patients with Asthma |
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| 引用本文： | 薛克营,周咏明,熊盛道,熊维宁,唐滔.Analysis of CD4^＋CD25^＋ Regulatory T Cells and Foxp3 mRNA in the Peripheral Blood of Patients with Asthma[J].华中科技大学学报(医学英德文版),2007,27(1):31-33. |
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| 作者姓名： | 薛克营 周咏明 熊盛道 熊维宁 唐滔 |
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| 作者单位： | Department of Respiratory Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Stem Cell Center Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Respiratory Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Respiratory Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Respiratory Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430030 China，Wuhan 430022 China，Wuhan 430030 China，Wuhan 430030 China，Wuhan 430030 China |
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| 摘 要： | The changes of CD4 CD25 regulatory T cells (CD4 CD25 Treg) and Foxp3 mRNA in peripheral blood mononuclear cells (PBMCs) from patients with asthma were investigated in order to elucidate the possible roles of CD4 CD25 Treg in the development of asthma. The peripheral blood samples were collected from 29 healthy controls (normal control group) and 78 patients with asthma which included 30 patients in exacerbation group, 25 patients in persistent group, and 23 patients in remission group. By using flow cytometry and RT-PCR, the CD4 CD25 Treg ratio and Foxp3 mRNA in PBMCs were detected. The CD4 CD25 Treg ratio and Foxp3 mRNA in PBMCs of exac-erbation and persistent groups were lower than that of remission and normal control groups (P<0.05). Although the CD4 CD25 Treg ratio and Foxp3 mRNA of remission group were also lower than that of normal control group, there was no significant difference between them (P>0.05). As compared with persistent group, exacerbation group had lower CD4 CD25 Treg ratio and Foxp3 mRNA (P<0.05). It was indicated that the decrease of CD4 CD25 Treg ratio and its function in PBMCs may be responsible for pathogenesis of asthma.
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| 关 键 词： | CD4^＋ CD25^＋ T细胞 外周血 哮喘 |
| 收稿时间： | 2006-04-06 |
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