半定量法201Tl双时相显像鉴别诊断甲状腺冷结节

为探讨甲状腺冷结节2 0 1Tl双时相显像的实用价值 ,取甲状腺单个冷结节患者 87例 ,静脉注射2 0 1Tl 12 1MBq后 15min显像及 12 0min延迟显像。按半定量法分别进行感兴趣区计数 ,计算结节组织与正常组织摄取比 (15min记为ER ,延迟记为DR)及滞留指数 RI =(DR -ER) /ER×10 0 %]。结果表明 ,ER、DR和RI的恶性与非恶性组之间差异显著 (P <0 .0 5 )。囊性腺瘤者ER、DR和RI均明显低于恶性者 (P <0 .0 1) ;炎症者与恶性者比较差异不显著 (P >0 .0 5 )。半定量法的灵敏度、特异性和诊断正确率明显优于目视法 ,ER分别与DR、RI之间比较有显著性差异 (P <0 .0 5 )。显像结果提示 ,半定量法2 0 1Tl诊断显像可明显提高甲状腺单个冷结节的良、恶性质的诊断效率 ,具有临床应用价值。

201Tl imaging of thyroid with cold nodule by semi-quantitative analysis

patients with cold thyroid nodule were imaged with 201Tl (early 15min, delayed 120min). Regions of interest (ROIs) were generated over the cold nodule and normal tissue on each image by semi-quantification method. The semi-quantitative analysis was performed by using a lesion to non-lesion ratio of early(ER) and delayed(DR) images. Retention index(RI) was calculated by dividing delayed-early subtraction to product ER. There was significant difference in the ER,DR and RI between malignant and benign lesions (P<0.05). The difference was not significant between carcinoma and inflammation (P>0.05), but there was significant difference between carcinoma and cystic adenoma (P<0.01).The sensitivity, specificity and accuracy using semi-quantification were significantly higher than visual method, and DR,RI were higher than ER (P<0.05). 201Tl imaging of thyroid cold nodule using ER,DR and RI have good clinical application value.