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| 复方丹参、脑复素、高压氧治疗新生儿缺氧缺血性脑病临床考察 | |
| 引用本文： | 殷宪敏,史宝海,杨晓雯,王淑珍,李睿.复方丹参、脑复素、高压氧治疗新生儿缺氧缺血性脑病临床考察[J].儿科药学杂志,2003,9(1):13-15. |
| 作者姓名： | 殷宪敏 史宝海 杨晓雯 王淑珍 李睿 |
| 作者单位： | 1. 泰山医学院附属医院,山东泰安,271000 2. 泰安市妇幼保健院 3. 泰安市第一人民医院 |
| 基金项目： | 山东省教育厅科研基金资助(199K09) |
| 摘 要： | 目的:探讨复方丹参、脑复素(含bFGF)联合高压氧(HBO)对新生儿缺氧缺血性脑病(HIE)的治疗作用。方法:用复方丹参、脑复素联合HBO治疗HIE 65例,同时设胞二磷胆碱对照组60例,两组均给予三项支持、三项对症治疗。观察治疗前后血清超氧化物歧化酶(SOD)和丙二醛(MDA)的水平、脑CT的改变、NBNA评分。结果:观察组治疗后SOD水平中度(679±131)μg/L、重度(654±129)μg/L;MDA水平中度(5.12±1.75)μmol/L、重度(5.23±1.64)μmol/L;脑CT正常中度27例、重度19例;NBNA评分正常中度29例、重度21例;上述各项指标结果均明显优于对照组,经统计学处理两组差异有显著性意义(P<0.05)。结论:复方丹参、脑复素联合HBO治疗HIE确有明显疗效。 |
| 关 键 词： | 脑缺氧 脑缺血 复方丹参 脑复素 高压氧 |
| 文章编号： | 1672-108X(2003)01-0013-03 |
| 修稿时间： | 2002年10月11 |
A study on clinic effect of Tanshinone, basic fibroblast growth factor and hyperbaric oxygen on hypoxic -ischemic encepholopathy in newborn |
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| YIN Xianmin,SHI Baohai,YANG Xiaowen,et al..A study on clinic effect of Tanshinone, basic fibroblast growth factor and hyperbaric oxygen on hypoxic -ischemic encepholopathy in newborn[J].Journal of Pediatric Pharmacy,2003,9(1):13-15. | |
| Authors: | YIN Xianmin SHI Baohai YANG Xiaowen |
| Abstract: | Objective: To study the clinic effect of Tanshinone, Naofusu (bFGF) and hyperbaric oxygen (HBO) on hypoxic-ischemic en-cepholopathy (HIE) in newborn. Methods: 125 cases with HIE from three hospitals were divided into two groups. 65 cases as observing group were treated by Tanshinone, bFGF and HBO and the rest 60 cases as control group were treated by cytidine 5-diphosphcholine (CDPC) . SOD, MDA, brain CT, NBNA marks after birth were taken as index to evaluate. Results: SOD, MDA, brain CT and NBNA marks in observing groups were better than that in control groups. There were a great difference between two groups (P < 0. 05) . Conclusion: It is very efective to use Tanshinone, bFGF and HBO in treating HIE in newborn. |
| Keywords: | Cerebral anoxia Cerebral ischemia Tanshinone Low molecular Peplides(Naofusu) Hyperbaric oxygen |
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