Acrylic bone cements: Effects of the poly(methyl methacrylate) powder size and chitosan addition on their properties |
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| Authors: | Tugba Endogan Aysel Kiziltay Gamze Torun Kose Nil Comunoglu Tahsin Beyzadeoglu Nesrin Hasirci |
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| Affiliation: | 1. Graduate Department of Polymer Science and Technology, Middle East Technical University, Ankara, Turkey;2. Central Laboratory, Middle East Technical University, Ankara, Turkey;3. Graduate Department of Biotechnology, Middle East Technical University, Ankara, Turkey;4. Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, Istanbul, Turkey;5. BIOMATEN—Center of Excellence in Biomaterials and Tissue Engineering, Ankara, Turkey;6. Department of Pathology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey;7. Department of Orthopaedics and Traumatology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey;8. Department of Chemistry, Middle East Technical University, Ankara, Turkey |
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| Abstract: | The effect of the particle size of poly(methyl methacrylate) (PMMA) and the incorporation of chitosan (CH) on the mechanical and thermal properties and the biocompatibility of acrylic bone cements were investigated. Three groups of bone cements were prepared with different PMMA particles. Groups 1 (BC1) and 2 (BC2) contained ground and sieved PMMA with particle sizes in the ranges 50–150 μm and 1–50 μm, and group 3 (BC3) contained synthesized PMMA microspheres with a size of about 1 μm. The mechanical properties of the three groups were similar, but their curing properties were significantly affected. The presence of CH improved the mechanical and thermal properties. For the BC1 group, the compressive strength increased more than 10 MPa, and the curing temperature decreased 12°. The cement having the optimum properties (BC1) was applied to rats, where it enhanced the bone bonding ability, and bioactivity was observed. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 39662. |
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| Keywords: | biocompatibility biomaterials composites |
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