两种运动试验对慢性阻塞性肺疾病患者运动低氧的比较

目的:对比6min步行试验(6MWT)与心肺运动试验(CPET)对慢性阻塞性肺疾病(COPD)患者运动低氧敏感性的差别。方法:选择30例稳定期COPD患者,分别行6MWT与CPET,两个试验的先后顺序随机,比较两种运动试验中运动低氧发生情况的差异。结果:6MWT中运动低氧发生率为46.6%(14/30),CPET中发生运动低氧发生率为50.0%(15/30),两种试验运动低氧的发生率,差异无统计学意义(P=0.796)。运动开始第2min至第6min,6MWT每分钟末脉搏血氧饱和度(SpO2)值低于心肺运动试验(P均0.05)。运动低氧发生时间6MWT(M=2)秒,明显早于CPET(M=8)秒(P=0.01)。结论:6MWT与CPET在COPD患者运动低氧发生率差异无统计学意义,运动低氧发生时间6MWT早于CPET。6MWT是一个简单、可行的COPD患者运动低氧的评价方案。

Sensitivity of two exercise test for oxygen desaturation in chronic obstructive pulmonary disease

Objective：To determine the difference of 6 minutes walk test（ 6MWT） and cardiopulmonary exercise test（ CPET） in oxygen desaturation in chronic obstructive pulmonary disease（ COPD）. Methods：A total of 30 stable patients with COPD were enrolled in this study. 6 minutes walk test and cardiopulmonary exercise test were performed respectively,and the order of two tests is random,finally,pulse oxygen saturation（ SpO2） and incidence of oxygen desaturation in the two test were compared. Results： 14 cases in 30 patients（ 46.6%） had hypoxemia during 6MWT,15 patients（ 50%） had hypoxemia during CPET. Incidence of hypoxemia in 6 MWT and CPET was similar（ P = 0. 796）. SpO2 value in 6 MWT was significantly lower than that in the CPET（ P〈0.05） between the second minutes and the sixth minutes after the test start. The time of hypoxemia occurred in 6 MWT（ M = 2） s is obviously earlier than that in the CPET（ M = 8） s（ P = 0. 01）.Conclusion： In value on oxygen desaturation in COPD,there is no significant difference in sensitivity of 6MWT and CPET. The time of hypoxemia occurred in 6 MWT is obviously earlier than that in the CPET. 6MWT is a simple and effective project in assessing exercise induced hypoxemia in COPD.