2000-2019年中国早发型胃癌和晚发型胃癌流行病学趋势分析题录

目的了解我国早发型胃癌和晚发型胃癌2000-2019年发病、死亡状况的变化趋势。方法收集全球疾病负担研究数据, 应用R 4.2.1软件分析中国人群2000-2019年不同性别、年龄和年份的胃癌发病率、死亡率及伤残调整生命年(DALY)等指标。结果 2019年早发型胃癌和晚发型胃癌粗发病率为7.06/10万(95%UI:6.63/10万～7.59/10万)和114.52/10万(95%UI:108.79/10万～121.63/10万), 粗死亡率分别为3.29/10万(95%UI:3.11/10万～3.50/10万)和81.88/10万(95%UI:78.15/10万～86.04/10万), 粗DALY率分别为156.48/10万(95%UI:148.82/10万～165.84/10万)和1 750.13/10万(95%UI:1 661.21/10万～1 852.99/10万)。早发型胃癌标化发病率由2000年的5.49/10万降至2019年的4.76/10万, 晚发型由2000年的143.45/10万降至2019年的123.02/10万;早发型胃癌标化死亡率由2000年的4.16/10...

Epidemiological trend of early-onset gastric cancer and late-onset gastric cancer in China from 2000 to 2019

Objective In order to understand the changing trends of gastric cancer incidence and mortality in early-onset and late-onset in China from 2000 to 2019. Methods The Global Burden of Disease research data was collected, and Excel and R 4.2.1 softwares were used to examine the incidence rate, mortality rate, and disability-adjusted life years (DALY) of Chinese people from 2000 to 2019, with a focus on gender, age, and year. Results In 2019, the crude incidence rates were 7.06/100 000 (95%UI:6.63/100 000-7.59/100 000) and 114.52/100 000 (95%UI:108.79/100 000-121.63/100 000) for early-and late-onset gastric cancer, respectively. The crude mortality rate for early-onset gastric cancer was 3.29/100 000 (95%UI:3.11/100 000-3.50/100 000), while the crude mortality rate for late-onset gastric cancer was 81.88/100 000 (95%UI:78.15/100 000-86.04/100 000). Additionally, the crude DALY rates for these two types of gastric cancer were 156.48/100 000 (95%UI:148.82/100 000-165.84/100 000) and 1 750.13/100 000 (95%UI:1 661.21/100 000-1 852.99/100 000). The standardized incidence of early-onset gastric cancer decreased from 5.49/100 000 in 2000 to 4.76/100 000 in 2019, and that of late-onset gastric cancer decreased from 143.45/100 000 in 2000 to 123.02/100 000 in 2019.The standardized mortality rate of early-onset gastric cancer decreased from 4.16/100 000 in 2000 to 2.18/100 000 in 2019, and that of late-onset gastric cancer decreased from 140.82/100 000 in 2000 to 91.49/100 000 in 2019. The standardized DALY rate for early-onset gastric cancer in 2019 was 105.87/100 000 (95%UI:87.98/100 000 -125.60/100 000), lower than 198.84/100 000 (95%UI:179.47/100 000-219.83/100 000) in 2000. The standardized DALY rate for late onset gastric cancer in 2019 was 1 821.11/100 000 (95%UI:1 509.42/100 000-2 158.53/100 000), lower than 2 932.52/100 000 (95%UI:2 665.92/100 000-3 252.60/100 000) in 2000. Conclusions The standardized mortality rate of early-onset gastric cancer in China showed a decreasing trend from 2000 to 2019. The standardized mortality rate of late onset gastric cancer showed a trend of first increasing and then decreasing. Notably, the incidence, mortality, and DALY of late-onset gastric cancer were significantly higher than those of early-onset gastric cancer during this period. Additionally, male incidence, mortality, and crude DALY rates were higher than female.