Growth and shaping of the fin and limb buds |
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Authors: | V G Borkhvardt |
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Affiliation: | (1) St. Petersburg State University, Universitetskaya nab.7/9, 199034 St. Petersburg, Russia |
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Abstract: | The development of the fin and limb buds involves a balance of centrifugal (active) and centripetal (passive) mechanical forces,
the first of which acts to move the walls of these structures away from each other and the second of which holds them together.
When the volume of the mesodermal core increases, the generated force meets with the resistance of the basal membrane, and
as a result, the limb bud has a tendency to acquire a cylindrical shape. Collagen fibers, individual mesenchymal cells, and
their groups hold together the dorsal and the ventral wall of the limb bud, prevent the movement of these walls away from
each other, and in this way direct bud growth along the proximodistal and the anteroposterior axes. The balance of the forces
which stretch the ectodermal layer and those which constrain it has also been observed in the development of other body parts. |
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Keywords: | vertebrates limb buds growth shaping mechanical factors |
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